{"id":"W4404591942","doi":"10.3390/metabo14120648","title":"Singlet Oxygen-Induced Mitochondrial Reset in Cancer: A Novel Approach for Ovarian Cancer Therapy","year":2024,"lang":"en","type":"article","venue":"Metabolites","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Fonds de Recherche du Québec - Santé; Université de Montréal; Ovarian Cancer Canada","keywords":"Warburg effect; Ovarian cancer; Cancer cell; Oxidative phosphorylation; Cancer research; Glycolysis; Mitochondrion; Apoptosis; Cancer; Reactive oxygen species; Metabolomics; Cell growth; Biology; Chemistry; Metabolism; Cell biology; Medicine; Biochemistry; Internal medicine; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002047871,0.0003091947,0.0003019981,0.0004151921,0.0002265803,0.0004865603,0.0002803964,0.0005457724,0.001401245],"category_scores_gemma":[0.0001330332,0.0001048418,0.0002872662,0.0002591437,0.0002884788,0.0004181209,0.0004525548,0.0007448193,0.0002053148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005032358,"about_ca_system_score_gemma":0.0003220092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000267054,"about_ca_topic_score_gemma":0.000634097,"domain_scores_codex":[0.9999108,0.00002150036,0.000004064728,0.00001678051,0.00002552225,0.00002131708],"domain_scores_gemma":[0.9999222,0.00001283271,0.0000283936,0.000008664276,0.00001285615,0.00001513915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003193119,0.0001742991,0.001167468,0.0006928342,0.00005237681,0.0002107264,0.00007539384,0.0005344447,0.9236849,0.003733288,0.001201285,0.06815361],"study_design_scores_gemma":[0.0001197559,0.003384135,0.007867363,0.0001755268,0.0001628718,0.002030448,0.000208153,0.003896317,0.8866655,0.00399087,0.09146322,0.00003575455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5922048,0.3039054,0.07527965,0.01127311,0.001045268,0.0003748525,0.0006403192,0.0009294989,0.01434709],"genre_scores_gemma":[0.9340258,0.05149356,0.008816974,0.0008333382,0.0002401165,0.0001171549,0.0002267124,0.00003313134,0.00421316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001401245,"threshold_uncertainty_score":0.004687607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04018346552156491,"score_gpt":0.3127643701673261,"score_spread":0.2725809046457612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}