{"id":"W4404593111","doi":"10.1093/glycob/cwae094","title":"A self-immolative Kdn-glycoside substrate enables high-throughput screening for inhibitors of Kdnases","year":2024,"lang":"en","type":"article","venue":"Glycobiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Glycomics Network; Natural Sciences and Engineering Research Council of Canada; Simon Fraser University","keywords":"Aspergillus fumigatus; Aspergillus terreus; Chemistry; High-throughput screening; Aspergillosis; Drug discovery; Small molecule; Aspergillus; Pathogen; Virulence; Chemical biology; Trichophyton rubrum; Microbiology; Fungus; Biochemistry; Biology; Immunology; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003098504,0.0005855162,0.0003301282,0.0003145777,0.0001214477,0.0002791516,0.0002787808,0.0003441208,0.0005555122],"category_scores_gemma":[0.0002559632,0.0001662615,0.0002441059,0.0003693227,0.000146098,0.0002715199,0.0002963374,0.0004889214,0.0002591787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002208178,"about_ca_system_score_gemma":0.0001891524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000417304,"about_ca_topic_score_gemma":0.0008840844,"domain_scores_codex":[0.9996948,0.00006924484,0.00002791939,0.00004936064,0.0001251117,0.00003354387],"domain_scores_gemma":[0.999896,0.0000237668,0.00002563206,0.00001559362,0.00002230797,0.00001671548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000473762,0.00006177171,0.0002136854,0.00004418613,0.00000837146,0.00003730432,0.000006690548,0.0003225476,0.9955137,0.00006164541,0.00004342006,0.003639224],"study_design_scores_gemma":[0.00001176972,0.0004447608,0.001157233,0.000005413654,0.00001391496,0.0001387865,0.000008148386,0.001187677,0.9954773,0.00002434539,0.001524445,0.000006329233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517342,0.003896793,0.03769011,0.0002324079,0.00004691884,0.0003045996,0.001157663,0.0002878173,0.004649522],"genre_scores_gemma":[0.9584202,0.002517878,0.034614,0.000131117,0.00001279131,0.0001293364,0.001815717,0.00004155449,0.002317507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005855162,"threshold_uncertainty_score":0.001858413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02474508172863691,"score_gpt":0.3033079106848803,"score_spread":0.2785628289562433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}