{"id":"W4404594393","doi":"10.21203/rs.3.rs-5359114/v1","title":"Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Candida auris; Biology; Antifungal drug; Echinocandin; Drug resistance; Galleria mellonella; Microbiology; Caspofungin; Echinocandins; Epigenetics; Virulence; Genetics; Gene; Candida albicans; Amphotericin B; Antifungal; Fluconazole","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626798,0.0001686122,0.0001646413,0.0001622513,0.0001192624,0.0004799446,0.0001595402,0.0002715209,0.002472235],"category_scores_gemma":[0.0002761529,0.00006834135,0.0001277313,0.0001224006,0.0001728769,0.0001781981,0.0002568947,0.0005041567,0.0002966761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000260412,"about_ca_system_score_gemma":0.000199594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004070739,"about_ca_topic_score_gemma":0.0007998206,"domain_scores_codex":[0.9999236,0.000008445914,0.000002572588,0.00001593026,0.00003169619,0.00001772486],"domain_scores_gemma":[0.9999514,0.00001244535,0.00001318991,0.000006241118,0.000008561984,0.000008166544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003860378,0.00005469867,0.0008909999,0.0002149192,0.00002519759,0.0002069554,0.00005083814,0.001404052,0.9135442,0.005186606,0.002401891,0.07563359],"study_design_scores_gemma":[0.00009746579,0.0003956164,0.008668795,0.00005932184,0.00008292896,0.0006632851,0.0001345803,0.01060297,0.9220778,0.004154986,0.05304083,0.00002151209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.902566,0.02757234,0.02862449,0.004366776,0.000802952,0.00009650998,0.001335858,0.0008532524,0.03378174],"genre_scores_gemma":[0.9798316,0.005267126,0.004789931,0.0002998172,0.00007370539,0.00002584691,0.0003707462,0.00005342107,0.009287774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002472235,"threshold_uncertainty_score":0.008270383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04253464183537446,"score_gpt":0.4038630964986141,"score_spread":0.3613284546632397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}