{"id":"W4404595278","doi":"10.1038/s41588-024-01975-5","title":"Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience","year":2024,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"HORIZON EUROPE European Innovation Council; National Heart, Lung, and Blood Institute; National Institutes of Health; Associação Fundo de Incentivo à Pesquisa; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft; European Commission; Sir Jules Thorn Charitable Trust; British Heart Foundation; Foundation for the National Institutes of Health; Amsterdam University Medical Centers; Hartstichting; American Heart Association; U.S. Department of Veterans Affairs; ZonMw; Aarne Koskelon Säätiö","keywords":"Mendelian randomization; Genome-wide association study; Biology; Dilated cardiomyopathy; Genetic architecture; Heart failure; Genome; Genetic association; Genetics; Disease; Cardiomyopathy; Quantitative trait locus; Gene; Single-nucleotide polymorphism; Internal medicine; Genetic variants; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001363446,0.0002930773,0.0003903963,0.001134536,0.000374229,0.000547073,0.0003046513,0.0003936136,0.001679347],"category_scores_gemma":[0.00248228,0.0001833065,0.0005570462,0.001130655,0.0004765202,0.0001987371,0.0007094598,0.0004659731,0.0001597719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001391432,"about_ca_system_score_gemma":0.0002036631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001201835,"about_ca_topic_score_gemma":0.001602,"domain_scores_codex":[0.9992129,0.0003104026,0.00005549598,0.0002390793,0.00009574299,0.00008631744],"domain_scores_gemma":[0.998869,0.0004352631,0.0003552541,0.0001707991,0.00005017572,0.0001195184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006619651,0.00005141638,0.9687458,0.00003909594,0.001050403,0.0007948707,0.0002145913,0.0003553463,0.01824061,0.0004863759,0.0002651437,0.009094371],"study_design_scores_gemma":[0.0000174483,0.00004780053,0.9973668,0.000006919578,0.0002343046,0.0004537823,0.0000802537,0.0004461863,0.000577206,0.0004777937,0.0002845762,0.000006891786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968684,0.0008649064,0.001342898,0.0001667206,0.000008280339,0.000005613208,0.0002345521,0.00002257166,0.0004860591],"genre_scores_gemma":[0.9991291,0.0002154341,0.0003733132,0.00002948455,0.000008133367,0.000003441606,0.0001308846,0.000004576006,0.0001056959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679347,"threshold_uncertainty_score":0.007210672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01093294111984463,"score_gpt":0.280054603426478,"score_spread":0.2691216623066334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}