{"id":"W4404595278","doi":"10.1038/s41588-024-01975-5","title":"Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience","year":2024,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"HORIZON EUROPE European Innovation Council; National Heart, Lung, and Blood Institute; National Institutes of Health; Associação Fundo de Incentivo à Pesquisa; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft; European Commission; Sir Jules Thorn Charitable Trust; British Heart Foundation; Foundation for the National Institutes of Health; Amsterdam University Medical Centers; Hartstichting; American Heart Association; U.S. Department of Veterans Affairs; ZonMw; Aarne Koskelon Säätiö","keywords":"Mendelian randomization; Genome-wide association study; Biology; Dilated cardiomyopathy; Genetic architecture; Heart failure; Genome; Genetic association; Genetics; Disease; Cardiomyopathy; Quantitative trait locus; Gene; Single-nucleotide polymorphism; Internal medicine; Genetic variants; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001044845,0.0002097142,0.0002648891,0.00008137263,0.000156535,0.00008260993,0.0001688208,0.0006728005,0.000006003198],"category_scores_gemma":[0.000692663,0.0002043866,0.000105138,0.0002206283,0.00002823685,0.000003967285,0.0001649059,0.0003888952,0.00001137005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008825797,"about_ca_system_score_gemma":0.0000886297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008004231,"about_ca_topic_score_gemma":0.00002936313,"domain_scores_codex":[0.998208,0.0002571486,0.0003105947,0.0006072857,0.0002487293,0.0003682777],"domain_scores_gemma":[0.9992051,0.0001292661,0.0001012834,0.0003278031,0.0001404516,0.00009607102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002560419,0.00006254232,0.8784225,0.00003445343,0.0005862238,0.00002102809,0.0003126088,0.0007831623,0.1133247,0.00005558223,0.003565591,0.002806047],"study_design_scores_gemma":[0.0003124649,0.0004139294,0.9832996,0.00001090414,0.0001557664,0.000007622026,0.0002617116,0.0001788143,0.0006913504,0.001423302,0.01295603,0.000288534],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831733,0.01076696,0.003936717,0.000425928,0.0007841598,0.0003195641,0.00003487327,0.00004177724,0.0005167212],"genre_scores_gemma":[0.9952344,0.0008534103,0.002002747,0.000525759,0.000257003,0.00003020798,0.00008435358,0.00003472963,0.000977378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1126333,"threshold_uncertainty_score":0.8334644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01093294111984463,"score_gpt":0.280054603426478,"score_spread":0.2691216623066334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}