{"id":"W4404595750","doi":"10.1101/2024.11.20.623831","title":"Deficits in forelimb reach learning in a mouse model of Fragile X syndrome","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Fragile X syndrome; FMR1; Autism spectrum disorder; Motor learning; Neuroscience; Knockout mouse; Forelimb; Psychology; Metric (unit); Autism; Motor skill; Cognition; Developmental psychology; Medicine; Fragile x; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006620526,0.002261556,0.0009696675,0.002707746,0.0007303655,0.0007903083,0.001080403,0.002498549,0.007068001],"category_scores_gemma":[0.0004944984,0.0006829519,0.001411467,0.0005755366,0.001352938,0.0008303402,0.0008709365,0.004267977,0.001570757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001175181,"about_ca_system_score_gemma":0.0007676742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002600777,"about_ca_topic_score_gemma":0.004644709,"domain_scores_codex":[0.9991589,0.00007526755,0.0001170861,0.0002969395,0.0002175348,0.0001343629],"domain_scores_gemma":[0.9990993,0.0001195218,0.0003337182,0.00009709215,0.00007453122,0.0002759017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006002042,0.0005519381,0.001029921,0.0001705029,0.00006130072,0.0007605792,0.0002085942,0.0009559918,0.9897037,0.001092167,0.0006453936,0.004219649],"study_design_scores_gemma":[0.0005137931,0.005072449,0.02455332,0.0005034943,0.0003567331,0.004260588,0.0004071789,0.01415242,0.9302042,0.002195379,0.01759822,0.0001822982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624766,0.001700708,0.02035206,0.001200138,0.0002400826,0.0002936273,0.007931039,0.002290023,0.003515727],"genre_scores_gemma":[0.9328602,0.002710432,0.02953036,0.0009050483,0.00006903912,0.001571211,0.006717383,0.0008633747,0.0247731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007068001,"threshold_uncertainty_score":0.02364486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110679107043274,"score_gpt":0.2093361418669508,"score_spread":0.1982293507965181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}