{"id":"W4404601358","doi":"10.21037/tcr-24-952","title":"The next frontier in breast cancer: genomic co-alteration and its impact on biology and treatment planning","year":2024,"lang":"en","type":"letter","venue":"Translational Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Frontier; Breast cancer; Biology; Computational biology; Oncology; Cancer; Internal medicine; Medicine; Genetics; Geography; Archaeology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00665389,0.0005706735,0.001583668,0.0006274667,0.0028811,0.003670655,0.001725483,0.04385522,0.003854789],"category_scores_gemma":[0.02510457,0.0006112433,0.001104304,0.00067697,0.004562498,0.004810529,0.002082932,0.04099252,0.002289836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003923763,"about_ca_system_score_gemma":0.004412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003934077,"about_ca_topic_score_gemma":0.009322388,"domain_scores_codex":[0.995986,0.00164632,0.0003314294,0.0004172448,0.001125329,0.0004937166],"domain_scores_gemma":[0.981434,0.01433924,0.000573037,0.0004428981,0.001451243,0.001759605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001609534,0.00006129195,0.00160748,0.00009569956,0.00003763511,0.003055919,0.0001833424,0.0001764748,0.0003905158,0.01088785,0.9498282,0.03351462],"study_design_scores_gemma":[0.0002342145,0.0001563883,0.002614369,0.0004372057,0.00006836473,0.005723148,0.0009198647,0.001235888,0.0005485892,0.08139451,0.9065611,0.0001064423],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003822203,0.003240353,0.0001452364,0.9833137,0.01163945,0.00000478002,0.00002159382,0.00001039696,0.001242287],"genre_scores_gemma":[0.008202942,0.004545136,0.0005140998,0.8854862,0.09739153,0.00002877221,0.00002679464,0.00001974432,0.00378483],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04385522,"threshold_uncertainty_score":0.03518957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0692619083684257,"score_gpt":0.4242672979618894,"score_spread":0.3550053895934637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}