{"id":"W4404610971","doi":"10.1093/neuonc/noae165.1302","title":"LTBK-02. EVALUATION OF PAXALISIB IN GBM AGILE PHASE 3 REGISTRATION PLATFORM TRIAL FOR NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Toronto","funders":"","keywords":"Glioblastoma; Agile software development; Medicine; Computer science; Oncology; Internal medicine; Cancer research; Software engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007752051,0.0001169247,0.0001732433,0.0001092467,0.00003179362,0.00002228919,0.00007485472,0.0002079489,0.00002068863],"category_scores_gemma":[0.0008968948,0.000103481,0.00006656818,0.0001184813,0.00006387287,0.00001503798,0.00003390484,0.0001028127,0.000001743719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006035306,"about_ca_system_score_gemma":0.0003596144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001086498,"about_ca_topic_score_gemma":0.0002468404,"domain_scores_codex":[0.9988016,0.0001471393,0.0003837523,0.000347504,0.0001706573,0.0001492865],"domain_scores_gemma":[0.9994054,0.0001234465,0.0001322733,0.0001604889,0.000126816,0.00005151441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01012735,0.0002810772,0.0000121083,0.00004933004,0.00001723536,0.000006284475,0.0001326201,0.00002295166,0.716894,0.000377341,0.008567053,0.2635126],"study_design_scores_gemma":[0.05440488,0.01634685,0.00003535132,0.0000456754,0.00007538152,0.00002214877,0.0001093933,0.00811702,0.6441396,0.0008129079,0.2756989,0.0001919092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950432,0.0008145279,0.0004106052,0.0006629043,0.001073918,0.001430246,0.00004947931,0.00001489495,0.0005001996],"genre_scores_gemma":[0.9983947,0.00022857,0.0001889677,0.0001398814,0.0004261869,0.000357052,0.0002165163,0.00001590255,0.00003226478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2671319,"threshold_uncertainty_score":0.4219834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04345240016882886,"score_gpt":0.3679641266827876,"score_spread":0.3245117265139588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}