{"id":"W4404610971","doi":"10.1093/neuonc/noae165.1302","title":"LTBK-02. EVALUATION OF PAXALISIB IN GBM AGILE PHASE 3 REGISTRATION PLATFORM TRIAL FOR NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Toronto","funders":"","keywords":"Glioblastoma; Agile software development; Medicine; Computer science; Oncology; Internal medicine; Cancer research; Software engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001342983,0.0006370941,0.0007129014,0.0002679185,0.0002784573,0.0007887671,0.0004982547,0.0006025209,0.01188875],"category_scores_gemma":[0.001062059,0.0001878596,0.0008095356,0.00029255,0.0003832801,0.0006127105,0.0003975531,0.001966513,0.001533112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000865967,"about_ca_system_score_gemma":0.001361682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001401542,"about_ca_topic_score_gemma":0.004814756,"domain_scores_codex":[0.9996324,0.000210461,0.00001345015,0.0000424382,0.00004161852,0.0000596804],"domain_scores_gemma":[0.9996628,0.00004659786,0.00007289288,0.0000320194,0.00003726336,0.0001483785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5721639,0.01082705,0.004578629,0.001881213,0.001348639,0.0001935923,0.0002242587,0.003747746,0.01863676,0.003711133,0.06012344,0.3225637],"study_design_scores_gemma":[0.7625518,0.1654329,0.01698691,0.0004638536,0.00102291,0.0004221263,0.0001894458,0.007541364,0.005705973,0.004389009,0.03521961,0.00007398887],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9330889,0.007994805,0.003008304,0.004532675,0.0008044085,0.005511354,0.01213528,0.001122539,0.03180171],"genre_scores_gemma":[0.9649646,0.002392326,0.002825455,0.00261904,0.0002392539,0.004668751,0.009471834,0.0001140607,0.01270456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01188875,"threshold_uncertainty_score":0.0397718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04345240016882886,"score_gpt":0.3679641266827876,"score_spread":0.3245117265139588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}