{"id":"W4404611180","doi":"10.1093/neuonc/noae165.1301","title":"LTBK-01. PHASE 3 STELLAR STUDY SHOWS EFLORNITHINE IMPROVES OVERALL SURVIVAL (OS) AND PROGRESSION FREE SURVIVAL (PFS) IN PATIENTS WITH RECURRENT 2021 WHO ASTROCYTOMA, IDH-MUTANT GRADE 3","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; CancerCare Manitoba","funders":"","keywords":"Eflornithine; Astrocytoma; Mutant; Oncology; Progression-free survival; Overall survival; Internal medicine; Medicine; Cancer research; Biology; Glioblastoma; Genetics; Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001027759,0.0007772031,0.001241857,0.0002449588,0.0002785659,0.0008041637,0.0005395133,0.0007589618,0.004414632],"category_scores_gemma":[0.0005010269,0.0002774569,0.001312275,0.0002429842,0.0004929103,0.0004948218,0.0002416204,0.001948119,0.001104968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006713485,"about_ca_system_score_gemma":0.001134022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009645393,"about_ca_topic_score_gemma":0.004239566,"domain_scores_codex":[0.9997739,0.0001048568,0.00001484442,0.00003352772,0.00002421059,0.0000485672],"domain_scores_gemma":[0.9996405,0.00004632375,0.0000812818,0.00002657601,0.00003012445,0.0001751503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7999379,0.02264757,0.007957727,0.001307968,0.001833444,0.0001809363,0.0001655397,0.001906069,0.04497237,0.000389454,0.008827544,0.1098734],"study_design_scores_gemma":[0.6014617,0.3607306,0.02281124,0.0001302442,0.001382002,0.0003636449,0.0001030288,0.001513596,0.005814496,0.0003986172,0.005248073,0.00004277025],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888129,0.003568527,0.0003744895,0.0007496118,0.0001727656,0.0009721745,0.001866926,0.0001694443,0.003313128],"genre_scores_gemma":[0.9875125,0.001882228,0.001017523,0.001182194,0.0001090518,0.001102395,0.003608255,0.00003697345,0.00354883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004414632,"threshold_uncertainty_score":0.01476836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228329439335487,"score_gpt":0.2937838626122831,"score_spread":0.2815005682189282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}