{"id":"W4404622530","doi":"10.1101/2024.11.21.624660","title":"Transient histone deacetylase inhibition induces cellular memory of gene expression and three-dimensional genome folding","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Gender and Health","funders":"","keywords":"Histone deacetylase; Cell biology; Transient (computer programming); HDAC11; Gene; Gene expression; Histone; Histone deacetylase inhibitor; Genome; HDAC10; Chemistry; Biology; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008057574,0.0001886819,0.0001776757,0.0001136944,0.00008155221,0.0002431888,0.0002018991,0.0001568891,0.0009827549],"category_scores_gemma":[0.00007109482,0.0001204286,0.0001417576,0.0000944428,0.0002515309,0.0001067732,0.0002444979,0.0004399209,0.00020587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002515132,"about_ca_system_score_gemma":0.00009569164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004836169,"about_ca_topic_score_gemma":0.0007194082,"domain_scores_codex":[0.9999315,0.000005812094,0.00000540485,0.00001736533,0.00002249741,0.00001742768],"domain_scores_gemma":[0.9999207,0.00001418992,0.0000237895,0.00001792824,0.000006863199,0.00001636698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002842583,0.000005808763,0.00010269,0.000006627638,0.000002024815,0.00001065231,0.000003964486,0.00006097686,0.999387,0.00005410603,0.00001723925,0.0003203709],"study_design_scores_gemma":[0.00000382353,0.00003989061,0.001901091,8.333801e-7,0.000002201766,0.00001986693,0.000005041498,0.0005915759,0.9969587,0.00002948547,0.000445994,0.000001508369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934356,0.0004346157,0.004395143,0.00006793066,0.00002889419,0.0000126945,0.0003161934,0.0001384511,0.001170404],"genre_scores_gemma":[0.9963645,0.0001506557,0.001458121,0.00004657977,0.000005657199,0.000017489,0.0002105346,0.0000288849,0.001717489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009827549,"threshold_uncertainty_score":0.003287673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008002156873700603,"score_gpt":0.2016751768216594,"score_spread":0.1936730199479588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}