{"id":"W4404625127","doi":"10.1038/s41397-024-00351-0","title":"Polygenic score analyses on antidepressant response in late-life depression, results from the IRL-GRey study","year":2024,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; McMaster University; Impact; Thrombosis and Atherosclerosis Research Institute; Population Health Research Institute; University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Depression (economics); Antidepressant; Venlafaxine; Psychiatry; Medicine; Major depressive disorder; Internal medicine; Schizophrenia (object-oriented programming); Bipolar disorder; Logistic regression; Clinical psychology; Psychology; Anxiety; Lithium (medication); Mood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002805485,0.0002822368,0.0003780328,0.0002692982,0.0003886762,0.0002621422,0.0004702243,0.00006575071,0.0002637543],"category_scores_gemma":[0.0009174031,0.0001489017,0.0002633251,0.0005155016,0.00008990186,0.0001838667,0.0001576931,0.001654864,0.0002041895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001759809,"about_ca_system_score_gemma":0.0003830367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002075509,"about_ca_topic_score_gemma":0.00004285838,"domain_scores_codex":[0.9966041,0.001228671,0.0007636936,0.0004305963,0.000596168,0.0003767289],"domain_scores_gemma":[0.9969286,0.001930033,0.0002204622,0.0006071691,0.0001047071,0.0002090536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.104572,0.003693193,0.3410189,0.00003251755,0.005099225,0.006390247,0.02321828,0.04196883,0.4414268,0.00001550011,0.01626826,0.01629632],"study_design_scores_gemma":[0.0116935,0.0004471981,0.9488809,0.0005395742,0.001910699,0.0007075078,0.007293143,0.02187613,0.001895144,0.0002333183,0.004070447,0.0004524867],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809827,0.005981007,0.00007244883,0.01128534,0.0006702427,0.0006626207,0.0001107405,0.00005671378,0.0001781567],"genre_scores_gemma":[0.996431,0.0009475617,0.00001791547,0.001560242,0.0006110682,0.00001323729,0.00001310879,0.00006355523,0.0003422991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.607862,"threshold_uncertainty_score":0.7189652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.150323195848316,"score_gpt":0.4233801586855074,"score_spread":0.2730569628371914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}