{"id":"W4404625127","doi":"10.1038/s41397-024-00351-0","title":"Polygenic score analyses on antidepressant response in late-life depression, results from the IRL-GRey study","year":2024,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Attention Deficit Hyperactivity Disorder","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; McMaster University; Impact; Thrombosis and Atherosclerosis Research Institute; Population Health Research Institute; University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Depression (economics); Antidepressant; Venlafaxine; Psychiatry; Medicine; Major depressive disorder; Internal medicine; Schizophrenia (object-oriented programming); Bipolar disorder; Logistic regression; Clinical psychology; Psychology; Anxiety; Lithium (medication); Mood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002341986,0.0008443442,0.0009849642,0.0007984815,0.0005583714,0.0008127611,0.0007403564,0.0009280488,0.001940827],"category_scores_gemma":[0.004360388,0.0003285097,0.002336732,0.00168389,0.0003549351,0.0004712359,0.001044486,0.0008717821,0.0002737321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003358476,"about_ca_system_score_gemma":0.0003068048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02111118,"about_ca_topic_score_gemma":0.02502985,"domain_scores_codex":[0.9979664,0.001072609,0.0001376207,0.0005365615,0.0001512046,0.0001355826],"domain_scores_gemma":[0.9976361,0.0007295214,0.0005934885,0.00059135,0.0002223581,0.0002272325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003690376,0.00005615315,0.9810241,0.00008538603,0.006021568,0.0004293365,0.0002391274,0.0006521397,0.002617582,0.0002051724,0.0007536847,0.004225235],"study_design_scores_gemma":[0.00006218431,0.0001216558,0.9975786,0.000008786424,0.001195419,0.0001195066,0.00005912282,0.0004701987,0.00006122426,0.00009443495,0.000221051,0.000007893446],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956247,0.0009768098,0.00046737,0.0001345011,0.00001344246,0.00001052278,0.002269091,0.00002082715,0.0004828656],"genre_scores_gemma":[0.9978672,0.0001667754,0.000200772,0.00004329854,0.00001531758,0.0000108472,0.001406146,0.00001134953,0.0002780603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02111118,"threshold_uncertainty_score":0.04197663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.150323195848316,"score_gpt":0.4233801586855074,"score_spread":0.2730569628371914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}