{"id":"W4404625463","doi":"10.1200/po.24.00331","title":"Safety and Efficacy of Osimertinib in Patients With Non–Small-Cell Lung Cancer and Uncommon Tumoral Epidermal Growth Factor Receptor Mutations: A Systematic Review and Single-Arm Meta-Analysis","year":2024,"lang":"en","type":"review","venue":"JCO Precision Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Osimertinib; T790M; Medicine; Lung cancer; Internal medicine; Meta-analysis; Epidermal growth factor receptor; Oncology; Cochrane Library; Adverse effect; Gastroenterology; Cancer; Gefitinib; Erlotinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004267089,0.0005145421,0.007211801,0.000602854,0.00005788235,0.00002698343,0.00009466187,0.000240191,0.0001350745],"category_scores_gemma":[0.0002729812,0.0002837198,0.0005499975,0.0009099522,0.0001047601,0.00007955532,0.0001143603,0.000331381,0.00000343953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004845041,"about_ca_system_score_gemma":0.0004711546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001526761,"about_ca_topic_score_gemma":0.000131419,"domain_scores_codex":[0.996588,0.0004995061,0.001706668,0.0007012485,0.000271319,0.0002332903],"domain_scores_gemma":[0.9969286,0.001258765,0.00103352,0.000360934,0.000237404,0.0001807939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0001910166,0.001336152,0.001395917,0.8588167,0.0767877,0.00003501929,0.0007327843,0.000002588265,2.716311e-7,0.000009593149,0.0001691689,0.06052306],"study_design_scores_gemma":[0.002651594,0.00136671,0.0008098004,0.0842971,0.9043266,0.00002148469,0.00002986739,0.00002286979,7.572009e-7,0.000003842663,0.006170768,0.0002985996],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001032099,0.991357,0.00002694577,0.0002593214,0.00007022358,0.006677436,0.000443305,0.00001684814,0.0001168382],"genre_scores_gemma":[0.002035072,0.9951584,0.0008159221,0.0001502025,0.00001719955,0.001020029,0.0003918362,0.00005361824,0.0003577601],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8275389,"threshold_uncertainty_score":0.9999615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05529877687620812,"score_gpt":0.3967880637316402,"score_spread":0.3414892868554321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}