{"id":"W4404628514","doi":"10.1002/anie.202421258","title":"Development and Applications of an Amide Linchpin Reagent","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Reagent; Chemoselectivity; Chemistry; Amide; Electrophile; Isocyanate; Electrophilic amination; Combinatorial chemistry; Amination; Functional group; Reactivity (psychology); Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005316754,0.0004962608,0.000182649,0.0003104219,0.000178599,0.0003103932,0.0003317476,0.0004064787,0.0009798622],"category_scores_gemma":[0.0003116151,0.0001609784,0.0002268071,0.0001466803,0.0002541741,0.0003952137,0.0003638259,0.0005916926,0.0006277768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003743916,"about_ca_system_score_gemma":0.0003272955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003561599,"about_ca_topic_score_gemma":0.000486219,"domain_scores_codex":[0.9997076,0.00005469175,0.00002420834,0.00007185442,0.00009679282,0.00004477608],"domain_scores_gemma":[0.9998245,0.00002482473,0.00004944016,0.00002436952,0.00003672267,0.00004019748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002596624,0.00002206921,0.0001038699,0.00006358668,0.000003996828,0.0001213711,0.00002672748,0.0001912436,0.9897159,0.0008868375,0.00008275727,0.008755711],"study_design_scores_gemma":[0.000006632597,0.0003447965,0.0002832581,0.000005558456,0.000007573139,0.0003100284,0.000005892777,0.0005490874,0.9898072,0.00006279763,0.008611657,0.000005577951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7844276,0.01201243,0.1658654,0.0007584592,0.0002278978,0.0008143499,0.0005776274,0.0008184132,0.03449775],"genre_scores_gemma":[0.8825594,0.005807156,0.1020127,0.0002216419,0.00009119921,0.0001918013,0.0004954977,0.00006903926,0.008551635],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0009798622,"threshold_uncertainty_score":0.003278017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906370032006771,"score_gpt":0.2996359663963435,"score_spread":0.2805722660762758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}