{"id":"W4404628858","doi":"10.1002/ange.202421258","title":"Development and Applications of an Amide Linchpin Reagent","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Reagent; Chemistry; Chemoselectivity; Amide; Electrophile; Isocyanate; Electrophilic amination; Combinatorial chemistry; Amination; Functional group; Reactivity (psychology); Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005265689,0.000509265,0.0001773248,0.0003109954,0.0001683949,0.0002829746,0.0003237052,0.0003769716,0.0009806793],"category_scores_gemma":[0.0002722257,0.0001469362,0.0002123463,0.0001417585,0.0002400386,0.0003426637,0.0003369668,0.0005226947,0.0005549915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00036862,"about_ca_system_score_gemma":0.0002824118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003406598,"about_ca_topic_score_gemma":0.0004418628,"domain_scores_codex":[0.9997321,0.00005464575,0.00002276284,0.00006725209,0.0000779679,0.00004532591],"domain_scores_gemma":[0.9998333,0.00002243196,0.00004948476,0.00002381216,0.00003276262,0.0000381038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002300983,0.00002231482,0.00009915264,0.00004319052,0.000003842982,0.000102189,0.00002022635,0.0001691477,0.9935125,0.0005976029,0.00005796471,0.00534904],"study_design_scores_gemma":[0.000006630765,0.0003191849,0.0002490999,0.000003340638,0.000005741504,0.0002000494,0.000003930645,0.0004861523,0.9945216,0.00004115167,0.004159033,0.000004127471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8786508,0.005389203,0.09228917,0.0004139849,0.0001481347,0.0005316038,0.000384343,0.000520451,0.02167239],"genre_scores_gemma":[0.9410226,0.002128047,0.05156133,0.0001121797,0.00005037449,0.0001057913,0.0003089931,0.00004206996,0.004668691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009806793,"threshold_uncertainty_score":0.003280699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02280117200196442,"score_gpt":0.2902693598904584,"score_spread":0.267468187888494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}