{"id":"W4404628858","doi":"10.1002/ange.202421258","title":"Development and Applications of an Amide Linchpin Reagent","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Reagent; Chemistry; Chemoselectivity; Amide; Electrophile; Isocyanate; Electrophilic amination; Combinatorial chemistry; Amination; Functional group; Reactivity (psychology); Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000210431,0.000143042,0.000166781,0.00002701426,0.00004124262,0.00002966808,0.0001569563,0.0001142408,0.0008234865],"category_scores_gemma":[0.0000464092,0.0001392711,0.00003749101,0.0001304401,0.00008019878,0.00004815523,0.00008232178,0.0001273106,0.00001347549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007008422,"about_ca_system_score_gemma":0.0001004389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009179515,"about_ca_topic_score_gemma":0.000003113781,"domain_scores_codex":[0.9990662,0.000005263378,0.0002707033,0.0003418068,0.0001570909,0.0001589083],"domain_scores_gemma":[0.9993243,0.0001056558,0.00004754504,0.0003759569,0.00003019265,0.0001163128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003978808,0.00004105208,0.00002840258,0.0005179132,0.00004154201,0.000006491646,0.0005246318,1.453353e-7,0.9362403,0.00009480131,0.0001258749,0.06237489],"study_design_scores_gemma":[0.00009202647,0.000002418725,0.00001504487,0.00009022051,0.00003110432,0.00003074159,0.0002508429,0.00001286009,0.8320228,0.000207409,0.1671165,0.0001279681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449582,0.002874194,0.0008834042,0.0001228915,0.00004739903,0.00008733911,0.00003570538,0.0002525213,0.05073841],"genre_scores_gemma":[0.9537848,0.0001502954,0.04066765,0.00003401698,0.0004006036,0.0001150755,0.00009464654,0.00005874738,0.004694181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1669906,"threshold_uncertainty_score":0.9016599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02280117200196442,"score_gpt":0.2902693598904584,"score_spread":0.267468187888494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}