{"id":"W4404629655","doi":"10.1186/s10020-024-01000-9","title":"TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study","year":2024,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"Natural Science Foundation of Gansu Province; National Natural Science Foundation of China; Lanzhou University","keywords":"TIMP1; Osteoporosis; Osteoblast; Cancer research; Endocrinology; Medicine; Internal medicine; Chemistry; In vitro; Gene expression; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005463377,0.0004623075,0.0005198301,0.0003468423,0.0003719345,0.0004187973,0.000299041,0.0003808819,0.002278338],"category_scores_gemma":[0.0001834007,0.000173232,0.000791311,0.0003115278,0.0002949684,0.00023121,0.0001553209,0.0009498721,0.000699011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005063426,"about_ca_system_score_gemma":0.000520481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035545,"about_ca_topic_score_gemma":0.001738001,"domain_scores_codex":[0.9997445,0.0000331787,0.00002204339,0.00004136495,0.00009021305,0.00006865685],"domain_scores_gemma":[0.9998265,0.00001950083,0.00005242561,0.00001807976,0.00004252805,0.00004090768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001010414,0.000334759,0.000797683,0.0003405579,0.00003767835,0.0001196433,0.00002637127,0.0001479244,0.9932995,0.000086722,0.000376553,0.003422235],"study_design_scores_gemma":[0.0002747421,0.001926626,0.01126686,0.00003664237,0.0002034902,0.0006681997,0.00009421041,0.001693319,0.9771506,0.0001015547,0.006565889,0.00001776678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647964,0.02271495,0.006840412,0.0008590778,0.0002935485,0.0001399466,0.001746846,0.0001927024,0.002416131],"genre_scores_gemma":[0.9795271,0.01039153,0.003929804,0.0002589871,0.0001080771,0.0001342182,0.001942272,0.00003280631,0.003675176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002278338,"threshold_uncertainty_score":0.007621765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179614493525692,"score_gpt":0.2877808663251993,"score_spread":0.2759847213899424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}