{"id":"W4404636532","doi":"10.3390/molecules29235525","title":"Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues","year":2024,"lang":"en","type":"review","venue":"Molecules","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Glial cell line-derived neurotrophic factor; Neurotrophic factors; Ciliary neurotrophic factor; Microglia; Neurotrophin; GDNF family of ligands; Neuroscience; Leukemia inhibitory factor; Biology; Brain-derived neurotrophic factor; Cell biology; Immunology; Interleukin 6; Cytokine; Inflammation; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002561849,0.0006436835,0.000891466,0.002210757,0.0001791094,0.0006893402,0.0003936861,0.0005308677,0.002255688],"category_scores_gemma":[0.0002792362,0.000167619,0.0003207854,0.001787199,0.0002651517,0.0007214118,0.0004052107,0.0007600196,0.001105739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003112419,"about_ca_system_score_gemma":0.0008885797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007448923,"about_ca_topic_score_gemma":0.001386371,"domain_scores_codex":[0.9998971,0.00001439984,0.00001917476,0.00001977359,0.00003825753,0.00001119313],"domain_scores_gemma":[0.9999051,0.00003836295,0.00001852058,0.000003065468,0.00002481835,0.00001014853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006746766,0.00005963421,0.0002783589,0.02137581,0.00009280564,0.0002657746,0.00006726465,0.0002862513,0.005470635,0.003461546,0.008807262,0.9597672],"study_design_scores_gemma":[0.00001952185,0.0001402757,0.001834486,0.004638813,0.0002190425,0.00233635,0.00008633167,0.00008442941,0.002224813,0.001819754,0.9865747,0.00002144551],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004274877,0.9976896,0.0001659958,0.0001656944,0.00008470511,0.000007892293,0.00003789895,0.000007604014,0.00141313],"genre_scores_gemma":[0.001699973,0.9971448,0.0003132307,0.0001005668,0.00006344514,0.000009752462,0.0000581061,0.000001364475,0.000608771],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002255688,"threshold_uncertainty_score":0.007546008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04241175335051085,"score_gpt":0.2578251898393805,"score_spread":0.2154134364888696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}