{"id":"W4404636723","doi":"10.1002/ejhf.3516","title":"State of the Art and Perspectives of Gene Therapy in Heart Failure. A Scientific Statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases","year":2024,"lang":"en","type":"review","venue":"European Journal of Heart Failure","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"H2020 European Research Council; Instituto de Salud Carlos III; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; National Institutes of Health; Deutsche Krebshilfe; Norges Forskningsråd; Ministero della Salute; Innovative Medicines Initiative; Hartstichting; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; King's College London; Fondation Leducq; Deutsches Zentrum für Herz-Kreislaufforschung; European Commission; British Heart Foundation; Dutch Cardiovascular Alliance; Deutsche Forschungsgemeinschaft; UK Research and Innovation; Foundation for Cardiovascular Research","keywords":"Heart failure; Medicine; Genetic enhancement; Disease; Modalities; CRISPR; Gene delivery; Genome editing; Bioinformatics; Heart disease; Intensive care medicine; Gene; Cardiology; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001581371,0.0008151376,0.001275697,0.002211589,0.000324554,0.001331083,0.0009690985,0.00183447,0.002683633],"category_scores_gemma":[0.001166895,0.0002950387,0.0005959456,0.001712773,0.001152302,0.002059322,0.0008534315,0.003287802,0.001619419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007363566,"about_ca_system_score_gemma":0.001223758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008193463,"about_ca_topic_score_gemma":0.001292416,"domain_scores_codex":[0.9996095,0.0000820896,0.00005274237,0.00006058614,0.0001597734,0.00003526023],"domain_scores_gemma":[0.999151,0.0005660802,0.00006262229,0.00002313207,0.0001349137,0.00006215944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008771808,0.00007964324,0.0001222597,0.01367004,0.0000619167,0.0002248152,0.00009875774,0.0003909876,0.002266555,0.011709,0.06456245,0.9067259],"study_design_scores_gemma":[0.00001451752,0.00008619796,0.0003493922,0.002333063,0.0000354251,0.0007933907,0.00003701463,0.00007828297,0.000365915,0.003199979,0.992691,0.00001591711],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003906548,0.9980423,0.0001054392,0.0006749238,0.0004886924,0.000001965546,0.000006400283,0.000004273555,0.0006367587],"genre_scores_gemma":[0.0003420018,0.9980937,0.0001582638,0.0004563245,0.0005389486,0.000004403874,0.00001160032,0.000001604595,0.0003931353],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002683633,"threshold_uncertainty_score":0.008977652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01962384967265613,"score_gpt":0.2566767588370522,"score_spread":0.237052909164396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}