{"id":"W4404636723","doi":"10.1002/ejhf.3516","title":"State of the Art and Perspectives of Gene Therapy in Heart Failure. A Scientific Statement of the Heart Failure Association of the ESC, the ESC Council on Cardiovascular Genomics and the ESC Working Group on Myocardial & Pericardial Diseases","year":2024,"lang":"en","type":"review","venue":"European Journal of Heart Failure","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"H2020 European Research Council; Instituto de Salud Carlos III; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; National Institutes of Health; Deutsche Krebshilfe; Norges Forskningsråd; Ministero della Salute; Innovative Medicines Initiative; Hartstichting; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; King's College London; Fondation Leducq; Deutsches Zentrum für Herz-Kreislaufforschung; European Commission; British Heart Foundation; Dutch Cardiovascular Alliance; Deutsche Forschungsgemeinschaft; UK Research and Innovation; Foundation for Cardiovascular Research","keywords":"Heart failure; Medicine; Genetic enhancement; Disease; Modalities; CRISPR; Gene delivery; Genome editing; Bioinformatics; Heart disease; Intensive care medicine; Gene; Cardiology; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004044024,0.0003717002,0.001078558,0.00008341285,0.0001906744,0.0000985807,0.0005191705,0.00008798319,0.00000275489],"category_scores_gemma":[0.0002678455,0.0001655745,0.001622158,0.0003594747,0.0005211973,0.000009228322,0.0002737489,0.0006518512,9.452496e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001410066,"about_ca_system_score_gemma":0.0004418608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001049405,"about_ca_topic_score_gemma":0.0000494762,"domain_scores_codex":[0.9954543,0.001977293,0.0009054239,0.000383598,0.001016317,0.000263075],"domain_scores_gemma":[0.9979573,0.0001506628,0.000673407,0.0008607735,0.0002986052,0.00005920401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004460557,0.002325735,0.01627866,0.01505359,0.05069271,0.00004443727,0.05490614,0.07806119,0.2367616,0.0004411135,0.3890438,0.1519304],"study_design_scores_gemma":[0.0009213268,0.0002272625,0.002637666,0.001750895,0.0007710727,0.00004828189,0.0006121635,0.000007222881,0.001096256,0.00001187599,0.9917349,0.0001810347],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1524568,0.8416444,0.00006022373,0.00371491,0.0006806711,0.00121484,0.0001989315,0.000003790887,0.0000253756],"genre_scores_gemma":[0.620682,0.3778298,0.0004610939,0.0001169332,0.0006390603,0.00001733631,0.00001252786,0.0001138713,0.0001274196],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.6026911,"threshold_uncertainty_score":0.6751934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01962384967265613,"score_gpt":0.2566767588370522,"score_spread":0.237052909164396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}