{"id":"W4404637142","doi":"10.1084/jem.20240699","title":"Heterozygous <i>BTNL8</i> variants in individuals with multisystem inflammatory syndrome in children (MIS-C)","year":2024,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; SickKids Foundation; Centre Hospitalier Universitaire Sainte-Justine; Institute of Infection and Immunity; Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; NIHR Imperial Biomedical Research Centre; Economic and Social Research Council; National Center for Advancing Translational Sciences; Medical Research Council; Horizon 2020 Framework Programme; Fondation pour la Recherche Médicale; National Institutes of Health; Rosetrees Trust; European Commission; Agència de Gestió d'Ajuts Universitaris i de Recerca; SCOR Corporate Foundation for Science; University College London; Wellcome Trust; Cancer Research UK; Institut des maladies génétiques Imagine; Francis Crick Institute; Centres de Recerca de Catalunya; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; Meyer Foundation; UK Research and Innovation; Rockefeller University; St. Giles Foundation; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Imperial College London; Fundació la Marató de TV3; Generalitat de Catalunya; National Institute for Health and Care Research; Howard Hughes Medical Institute","keywords":"Enteropathy; Biology; Intestinal permeability; Homeostasis; Inflammatory bowel disease; Immunology; Gene; Inflammation; Disease; Regulator; Genetics; Medicine; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003252228,0.0005481257,0.0003406152,0.0008479519,0.0005270613,0.0004129551,0.0002277365,0.0005655756,0.001949862],"category_scores_gemma":[0.001496257,0.0001765853,0.0004008321,0.0008155762,0.0005070809,0.0001852669,0.000379037,0.0003911101,0.0001721123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978825,"about_ca_system_score_gemma":0.000178805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002637011,"about_ca_topic_score_gemma":0.002448377,"domain_scores_codex":[0.9995804,0.00006843054,0.00004502575,0.0001688146,0.00007118712,0.00006615213],"domain_scores_gemma":[0.9994559,0.0001914539,0.0002049913,0.00003423554,0.00002951476,0.00008385591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009466573,0.00004254154,0.970402,0.00004014159,0.0001384731,0.00522917,0.0002860063,0.0003728236,0.01713978,0.000195853,0.0003163133,0.00489029],"study_design_scores_gemma":[0.00005171668,0.0003668103,0.9760081,0.00002289573,0.0001985146,0.01786414,0.0003616682,0.001061621,0.003090412,0.0001963934,0.0007600008,0.00001787966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991367,0.00007106092,0.0002671814,0.00002180207,0.00000415447,0.000007026636,0.0003015868,0.00001096216,0.0001795459],"genre_scores_gemma":[0.999365,0.00003173778,0.000341763,0.00001716308,0.000005413898,0.000005419921,0.0001738357,0.000005193101,0.00005440136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002637011,"threshold_uncertainty_score":0.006522894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182373384033811,"score_gpt":0.2814358230705227,"score_spread":0.2696120892301846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}