{"id":"W4404660300","doi":"10.1111/gtc.13184","title":"Generation of Monosomy 21q Human <scp>iPS</scp> Cells by <scp>CRISPR</scp> /Cas9‐Mediated Interstitial Megabase Deletion","year":2024,"lang":"en","type":"article","venue":"Genes to Cells","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences; Institute of Genetics; Japan Agency for Medical Research and Development; Support for Pioneering Research Initiated by the Next Generation","keywords":"Biology; Monosomy; Genetics; Chromosome 21; Transcriptome; Cas9; CRISPR; Gene; Induced pluripotent stem cell; Ploidy; X-inactivation; Chromosome; Molecular biology; Cell biology; Embryonic stem cell; Gene expression; X chromosome; Karyotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002249077,0.0003535835,0.0003293664,0.0003087458,0.000193062,0.0002743681,0.0002813034,0.0002765436,0.00156755],"category_scores_gemma":[0.0001600028,0.0002007203,0.0002464532,0.0002572859,0.0001966643,0.0001336605,0.0004216846,0.0005527502,0.0007510225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001609027,"about_ca_system_score_gemma":0.0002618051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003694605,"about_ca_topic_score_gemma":0.0006744064,"domain_scores_codex":[0.9998498,0.00001329726,0.00002191137,0.00003178717,0.00006469843,0.00001841531],"domain_scores_gemma":[0.9999064,0.00001682168,0.00002502649,0.00001905383,0.00001525214,0.00001743336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002375504,0.000009466908,0.0001702652,0.00004271938,0.000009131715,0.000137393,0.00002327462,0.0002468301,0.995766,0.0004908102,0.000180796,0.002899508],"study_design_scores_gemma":[0.00001302727,0.0001104812,0.002698345,0.00001071214,0.00003496835,0.0006976497,0.00002439825,0.002820051,0.9797956,0.0001584154,0.0136267,0.000009687595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8883031,0.001471166,0.09321957,0.0002343082,0.0001683031,0.0006583813,0.005687514,0.001013149,0.009244557],"genre_scores_gemma":[0.9314949,0.002231436,0.0457355,0.0001451144,0.0000324594,0.0004991672,0.008575651,0.000311425,0.01097441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00156755,"threshold_uncertainty_score":0.005243957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322786187091963,"score_gpt":0.2829114826768843,"score_spread":0.2696836208059646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}