{"id":"W4404663595","doi":"10.1101/2024.11.22.624315","title":"A meta-analysis of the effects of early life stress on the prefrontal cortex transcriptome suggests long-term effects on myelin","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; Douglas College; McGill University","funders":"International Brain Research Organization; Grinnell College; National Institute on Drug Abuse; Hope for Depression Research Foundation","keywords":"Prefrontal cortex; Transcriptome; Neuroscience; Myelin; Term (time); Psychology; Biology; Cognition; Gene expression; Genetics; Central nervous system; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006803,0.001426633,0.004144466,0.001931992,0.0007277203,0.002078928,0.001302969,0.001490627,0.003387362],"category_scores_gemma":[0.01370072,0.000703618,0.02077801,0.003903114,0.000615254,0.0007997859,0.001118329,0.001547637,0.0003276037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007373688,"about_ca_system_score_gemma":0.001107782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007607456,"about_ca_topic_score_gemma":0.01157982,"domain_scores_codex":[0.9940399,0.002751535,0.0006363938,0.001885459,0.0003692941,0.0003175283],"domain_scores_gemma":[0.9917566,0.005468338,0.0008145461,0.001200279,0.0005519611,0.0002082586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00668066,0.00005147058,0.202193,0.02653615,0.7232839,0.0004173941,0.0001905234,0.00325181,0.004227439,0.0008790581,0.005803236,0.02648531],"study_design_scores_gemma":[0.0005719779,0.0004344775,0.2309016,0.003266268,0.747821,0.0003793366,0.0001707865,0.002140901,0.001581511,0.002428703,0.01022976,0.00007361062],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2590705,0.6874827,0.01494998,0.003962944,0.001262252,0.0001560699,0.03052542,0.0003968801,0.002193271],"genre_scores_gemma":[0.9401222,0.04524883,0.003775071,0.001796609,0.0003149491,0.0002762113,0.007560042,0.0001757245,0.0007303988],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007607456,"threshold_uncertainty_score":0.03597814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03166178158567108,"score_gpt":0.253735033454395,"score_spread":0.222073251868724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}