{"id":"W4404666579","doi":"10.1002/cac2.12632","title":"PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer","year":2024,"lang":"en","type":"letter","venue":"Cancer Communications","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Breakthrough Breast Cancer","keywords":"Trastuzumab; Breast cancer; Biomarker; Oncology; Internal medicine; Acquired resistance; Medicine; Cancer; Cancer research; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008428995,0.0004113099,0.0004398809,0.0001302775,0.0001762029,0.00005379791,0.0005320709,0.0004583968,0.0000338167],"category_scores_gemma":[0.00001331084,0.0004173772,0.0001963299,0.0002207601,0.0003785858,0.00001613877,0.0002514624,0.0003051502,0.000001184282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005006909,"about_ca_system_score_gemma":0.0004056739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001843129,"about_ca_topic_score_gemma":0.002614797,"domain_scores_codex":[0.9982474,0.0001108477,0.0005012811,0.0006526331,0.0001393979,0.0003483719],"domain_scores_gemma":[0.9981052,0.00004565295,0.0002973678,0.001288799,0.0002115531,0.00005139182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005283199,0.001322673,0.004186965,0.006128111,0.005966094,0.0001012577,0.0044641,0.0002453625,0.2344154,0.0007343334,0.7044235,0.03272901],"study_design_scores_gemma":[0.006045884,0.0005102954,0.0511466,0.004331056,0.001615147,0.000105258,0.0002351192,0.0004123574,0.541288,0.001464944,0.3906594,0.00218595],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.09357148,0.5368848,0.0002257306,0.3249049,0.0003437336,0.003307936,0.04054189,0.00005415133,0.0001653811],"genre_scores_gemma":[0.9419988,0.03680922,0.001300281,0.007654944,0.0005751747,0.003612051,0.005227034,0.0001754048,0.002647026],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8484274,"threshold_uncertainty_score":0.9998278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540405219052927,"score_gpt":0.2892659662646147,"score_spread":0.2738619140740854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}