{"id":"W4404681640","doi":"10.1093/cercor/bhae465","title":"Neuronal viability/astrocyte activity ratio in the dorsolateral prefrontal cortex as a biomarker of Alzheimer’s dementia: a proton magnetic resonance spectroscopy study","year":2024,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Centre for Addiction and Mental Health; University of New Brunswick","funders":"W. Garfield Weston Foundation; Brain and Behavior Research Foundation","keywords":"Dorsolateral prefrontal cortex; Dementia; Neuroscience; Prefrontal cortex; Astrocyte; Proton magnetic resonance; Psychology; Biomarker; Dorsolateral; Alzheimer's disease; Nuclear magnetic resonance; Medicine; Chemistry; Pathology; Central nervous system; Cognition; Disease; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006303777,0.0003606469,0.0003258084,0.0006842607,0.0002763399,0.000417535,0.0002113573,0.0003165458,0.0005956613],"category_scores_gemma":[0.0009060075,0.0001821535,0.0001854021,0.0003617102,0.0002475317,0.0002363883,0.0002439486,0.0002186995,0.0001519065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002840688,"about_ca_system_score_gemma":0.0001712821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003187881,"about_ca_topic_score_gemma":0.003220137,"domain_scores_codex":[0.9998531,0.00002908856,0.00001361129,0.00004296051,0.00004287856,0.00001828985],"domain_scores_gemma":[0.9996222,0.0000511243,0.0001247226,0.00003116535,0.00008854978,0.0000821518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003937711,0.0003935406,0.9589605,0.00006135356,0.000381445,0.0008377417,0.0003603501,0.0001087058,0.02536279,0.00003328449,0.00008330702,0.009479241],"study_design_scores_gemma":[0.00005316603,0.0007495107,0.9955105,0.000004936555,0.000119549,0.001283964,0.0001530756,0.0002579681,0.001666654,0.00003695717,0.0001577478,0.000006051111],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993818,0.0002913665,0.0001097244,0.000009272631,0.000002139215,0.00001049105,0.0000388913,0.000001737671,0.0001545806],"genre_scores_gemma":[0.9995364,0.00008956094,0.0001927647,0.00001108994,0.000005247218,0.000007498323,0.0000502946,8.254463e-7,0.0001062603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003187881,"threshold_uncertainty_score":0.006338656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756484026067625,"score_gpt":0.325889110968356,"score_spread":0.2983242707076798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}