{"id":"W4404684984","doi":"10.11106/ijt.2024.17.2.299","title":"BRAF/MEK Inhibitors in Downstaging <i>BRAF</i><sup>V600E</sup> Mutated Papillary Thyroid Cancer to Allow Resection: Case Report and Literature Review","year":2024,"lang":"en","type":"article","venue":"International Journal of Thyroidology","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Resection; Papillary thyroid cancer; Cancer research; Thyroid cancer; Medicine; Mutation; Thyroid; Cancer; Internal medicine; Oncology; Biology; Gene; Genetics; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003444316,0.0007164133,0.0008326267,0.003182052,0.0005203419,0.001256355,0.0007975287,0.00174451,0.002004239],"category_scores_gemma":[0.0008434151,0.0003948192,0.0006815675,0.002360567,0.0006259552,0.001510023,0.0005350102,0.001077169,0.0009854514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000543436,"about_ca_system_score_gemma":0.0009332795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001052584,"about_ca_topic_score_gemma":0.001966816,"domain_scores_codex":[0.9996693,0.0000400157,0.0001126377,0.00005950075,0.00007199083,0.00004653905],"domain_scores_gemma":[0.9994985,0.0002005344,0.0001760447,0.00002821108,0.00004991045,0.00004673167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0002285313,0.0002091762,0.01437152,0.01455483,0.0003552593,0.5391209,0.0006507622,0.000824342,0.007234112,0.002294239,0.02330084,0.3968555],"study_design_scores_gemma":[0.00002361719,0.0001029284,0.005036777,0.002661953,0.0004210643,0.8567709,0.0005258553,0.0003756563,0.002488478,0.0007358691,0.1308146,0.00004227903],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01935961,0.969879,0.001119831,0.001694495,0.0005296473,0.00004818358,0.0001312952,0.00005320436,0.007184706],"genre_scores_gemma":[0.1465249,0.8452745,0.001660096,0.002014612,0.002352206,0.00003266599,0.0003114165,0.00002464799,0.001804959],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003182052,"threshold_uncertainty_score":0.006704867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307253849460719,"score_gpt":0.3361172216320514,"score_spread":0.3230446831374442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}