{"id":"W4404691520","doi":"10.1039/d4cb00233d","title":"Dynamic conformational equilibria in the active states of KRAS and NRAS","year":2024,"lang":"en","type":"article","venue":"RSC Chemical Biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"KRAS; Neuroblastoma RAS viral oncogene homolog; Chemistry; Mutation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104127,0.00004453229,0.00007507361,0.00002274142,0.000009214685,0.00001065772,0.00006439695,0.00005837554,0.0001631866],"category_scores_gemma":[0.00003458788,0.00002612011,0.00001328756,0.00005859855,0.0001561017,0.0000579169,0.00002731456,0.00006679851,0.00001359364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001272249,"about_ca_system_score_gemma":0.00001691964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001823707,"about_ca_topic_score_gemma":0.000005729438,"domain_scores_codex":[0.9996465,0.00002541885,0.0001113647,0.0000960653,0.00003711095,0.00008354188],"domain_scores_gemma":[0.999691,0.0002170574,0.00001957261,0.00005051604,0.00001145262,0.00001040415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002436735,0.000003415445,0.0000639699,0.00001823403,0.000002843306,4.458205e-7,0.0003868203,7.908365e-7,0.9897612,0.008350814,0.0001259476,0.001261131],"study_design_scores_gemma":[0.0002588916,0.00008945574,0.002005856,0.00002375439,0.00001161179,0.00003913209,0.000323454,0.002957074,0.9248601,0.06521887,0.004109411,0.0001023843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998213,0.000216846,0.00008573357,0.0003411355,0.0001436921,0.00004597601,0.00005161351,0.00001282423,0.0008891984],"genre_scores_gemma":[0.9996628,0.0000174567,0.0001193919,0.0000990097,0.00002609274,0.000004394963,0.00006075377,0.000001763274,0.000008335256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06490112,"threshold_uncertainty_score":0.1786779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006655521470904304,"score_gpt":0.2616720638069199,"score_spread":0.2550165423360156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}