{"id":"W4404693322","doi":"10.1093/jnci/djae306","title":"Childhood, adolescent, and young adulthood cancer risk in <i>BRCA1</i> or <i>BRCA2</i> pathogenic variant carriers","year":2024,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne; European Social Fund; National Cancer Institute; Instituto de Salud Carlos III; National Medical Research Council; Vedecká Grantová Agentúra MŠVVaŠ SR a SAV; Deutsche Krebshilfe; General Secretariat for Research and Technology; University of Melbourne; Lee Foundation; Royal Marsden NHS Foundation Trust; Department of Health and Social Care; Medical Research Council; National Institute on Handicapped Research; Institute of Cancer Research; National Health and Medical Research Council; Freistaat Sachsen; Cancer Research UK; Gray Foundation; European Regional Development Fund; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; National Institutes of Health; NIHR Cambridge Biomedical Research Centre; Terry Fox Foundation; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; European Commission","keywords":"Medicine; Breast cancer; Ovarian cancer; Cancer; Oncology; Relative risk; Internal medicine; Young adult; Family history; Genetic testing; Gynecology; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009581983,0.0001748703,0.0001757846,0.0007444424,0.0001749606,0.0003831003,0.0001974096,0.0003414768,0.001426843],"category_scores_gemma":[0.003579359,0.0001465447,0.0003982393,0.0006028098,0.0001972091,0.0002641472,0.0002604034,0.0003546846,0.00009955937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001975213,"about_ca_system_score_gemma":0.0002158613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004987033,"about_ca_topic_score_gemma":0.006304627,"domain_scores_codex":[0.9995924,0.0001253202,0.00003883389,0.0001222475,0.00006549055,0.00005573738],"domain_scores_gemma":[0.9969272,0.001010377,0.001550436,0.0001182608,0.0001361252,0.0002576102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005067907,0.000004046046,0.9987668,0.000007162182,0.00003891789,0.00004577329,0.0000262525,0.00002755547,0.00008729335,0.00001247789,0.00003066293,0.0009023874],"study_design_scores_gemma":[0.000002936956,0.000056449,0.9990309,0.00001589841,0.00006615948,0.0004270934,0.00007460007,0.00009209569,0.00007391076,0.00002796212,0.0001304939,0.000001460218],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977347,0.00153544,0.00009063412,0.00005772302,0.000005148571,0.000003376225,0.0002053597,0.000003173571,0.0003643875],"genre_scores_gemma":[0.9990098,0.0006308037,0.0001121519,0.00001892556,0.000008761074,0.000003129338,0.0001502225,0.000001629064,0.0000644291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004987033,"threshold_uncertainty_score":0.009916008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554469543989963,"score_gpt":0.294899584642527,"score_spread":0.2793548892026274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}