{"id":"W4404695232","doi":"10.1038/s41467-024-54409-5","title":"Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Deutsche Forschungsgemeinschaft; Deutschen Konsortium für Translationale Krebsforschung; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Bundesministerium für Bildung und Forschung; Diamond Light Source; McGill University; Bayer; Pfizer; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb","keywords":"ULK1; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008314268,0.0005254493,0.0003736754,0.0002374745,0.0002159611,0.000444363,0.0002889525,0.0003318663,0.001155471],"category_scores_gemma":[0.001224867,0.0001954409,0.0002136739,0.0002534003,0.0002111527,0.0003691915,0.000342038,0.0004055997,0.0003370683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003479946,"about_ca_system_score_gemma":0.0003048925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007959714,"about_ca_topic_score_gemma":0.001215138,"domain_scores_codex":[0.9994137,0.0001745515,0.00004892232,0.000084045,0.0001880653,0.00009056977],"domain_scores_gemma":[0.9994816,0.0001989185,0.0000833746,0.00003865556,0.0001407049,0.00005675988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190319,0.00007957145,0.000385419,0.00008282821,0.00001352999,0.0000478438,0.0000354797,0.00106108,0.9937312,0.00008092331,0.00006298054,0.004228717],"study_design_scores_gemma":[0.000008303989,0.0005427168,0.0009555483,0.0000109268,0.00001946305,0.00006891143,0.00003488121,0.001518092,0.9957765,0.00002639405,0.001029994,0.000008325566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856582,0.002509184,0.009387285,0.0001016248,0.00001672473,0.0001197926,0.000351327,0.0000886526,0.001767215],"genre_scores_gemma":[0.9781128,0.00277184,0.01646935,0.0001018717,0.000008776046,0.0001646711,0.0007097313,0.00006673648,0.001594392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001155471,"threshold_uncertainty_score":0.004397035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1173774244168576,"score_gpt":0.4758767248836345,"score_spread":0.3584993004667769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}