{"id":"W4404713207","doi":"10.1093/cid/ciae514","title":"Change in Blood Pressure, Weight, and Other Cardiovascular Disease Risk Factors After Switch From Protease Inhibitors to Dolutegravir: Post hoc Analysis of the 48-week Randomised Second-line Switch to Dolutegravir Trial","year":2024,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of Nairobi; Ministrstvo za zdravje; ViiV Healthcare","keywords":"Dolutegravir; Medicine; Post-hoc analysis; Blood pressure; Protease inhibitor (pharmacology); Randomized controlled trial; Internal medicine; Protease; Human immunodeficiency virus (HIV); Virology; Pharmacology; Antiretroviral therapy; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003256547,0.001886822,0.005159119,0.0003488873,0.0003597071,0.001488389,0.001004661,0.001764933,0.005895496],"category_scores_gemma":[0.003807618,0.0007108048,0.004559315,0.0003856181,0.0009966936,0.001295186,0.0007266756,0.003837615,0.0007333824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000925859,"about_ca_system_score_gemma":0.0009351554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002027694,"about_ca_topic_score_gemma":0.003316111,"domain_scores_codex":[0.9974252,0.001664031,0.0001081648,0.0003202437,0.000111515,0.0003707813],"domain_scores_gemma":[0.9972401,0.001257581,0.0003983024,0.0003446979,0.0001284554,0.0006309341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9925066,0.00118921,0.001029759,0.00009298933,0.001620209,0.00002172481,0.00002466732,0.0001921972,0.0006237269,0.00001534616,0.0002045587,0.002478991],"study_design_scores_gemma":[0.8995329,0.07886729,0.01617071,0.0000275536,0.003040939,0.00003849715,0.00007807825,0.0009266047,0.0007182127,0.0001304575,0.0004349605,0.00003385724],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966209,0.0009750341,0.000184779,0.0002326679,0.0002279578,0.0003512013,0.0007286174,0.00003421874,0.0006446395],"genre_scores_gemma":[0.9965857,0.0003612843,0.0002355563,0.0002591398,0.000232754,0.0003280605,0.0007909263,0.0000141904,0.00119245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005895496,"threshold_uncertainty_score":0.0197224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03256465490159331,"score_gpt":0.3364700757848292,"score_spread":0.3039054208832359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}