{"id":"W4404719809","doi":"10.1038/s41408-024-01187-4","title":"RSK1 dependency in FLT3-ITD acute myeloid leukemia","year":2024,"lang":"en","type":"article","venue":"Blood Cancer Journal","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Edward P. Evans Foundation; National Heart, Lung, and Blood Institute; McGill University; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; MPN Research Foundation; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Myeloid leukemia; Cancer research; Fms-Like Tyrosine Kinase 3; Leukemia; Biology; Cycloheximide; Immunology; Cell culture; Mutation; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045531,0.0002774032,0.000182916,0.0002169907,0.0001535914,0.0002451693,0.0001048755,0.0001385093,0.001143308],"category_scores_gemma":[0.0001098237,0.00008691604,0.0001817228,0.0001594218,0.0002302963,0.0001447642,0.0001557444,0.0003637624,0.0003083451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003653987,"about_ca_system_score_gemma":0.0001588198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002756182,"about_ca_topic_score_gemma":0.0007490063,"domain_scores_codex":[0.9998932,0.00001539842,0.00001146463,0.00002788379,0.00003047283,0.00002156553],"domain_scores_gemma":[0.9999255,0.000009608941,0.00003258444,0.0000106649,0.000004909274,0.00001679296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002202439,0.00003824291,0.00121226,0.00003780501,0.0000082439,0.0001065043,0.000008882222,0.0002082832,0.994752,0.0001619808,0.00007628126,0.00316928],"study_design_scores_gemma":[0.00001402842,0.0003697838,0.02539664,0.000003626318,0.00001686936,0.0009968084,0.00001858701,0.001073251,0.970093,0.00009654614,0.001915237,0.00000567791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971656,0.001091321,0.000536588,0.00007015574,0.00001141331,0.00000959147,0.0003737155,0.00006520899,0.0006763375],"genre_scores_gemma":[0.9980934,0.0004217317,0.0004486982,0.00002156647,0.000003506737,0.000008548415,0.0003867559,0.000007619014,0.0006081717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143308,"threshold_uncertainty_score":0.00382477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01795573993158491,"score_gpt":0.3294307861238656,"score_spread":0.3114750461922807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}