{"id":"W4404730089","doi":"10.1002/1878-0261.13770","title":"Loss of <i>SETD2</i> in wild‐type <i>VHL</i> clear cell renal cell carcinoma sensitizes cells to <scp>STF</scp> ‐62247 and leads to <scp>DNA</scp> damage, cell cycle arrest, and cell death characteristic of pyroptosis","year":2024,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"Canadian Cancer Society Research Institute; New Brunswick Innovation Foundation; Fondation de la recherche en santé du Nouveau-Brunswick; Cancer Research Institute","keywords":"Clear cell renal cell carcinoma; Cell cycle; Biology; Cancer research; Cell cycle checkpoint; Chromatin; DNA repair; Histone; DNA damage; Molecular biology; Cell; Gene; Genetics; DNA; Renal cell carcinoma; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003791216,0.0005271739,0.001142022,0.000492215,0.00006687267,0.00003992473,0.0002475956,0.0004107062,0.00001962504],"category_scores_gemma":[0.00007209826,0.0005321034,0.0001857537,0.0006649623,0.0002471138,0.00008163535,0.0002756309,0.0004970213,0.00008439779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000127801,"about_ca_system_score_gemma":0.0003908219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001459488,"about_ca_topic_score_gemma":0.00001574858,"domain_scores_codex":[0.9967934,0.0003006248,0.0007856605,0.0009386066,0.0004048579,0.0007768103],"domain_scores_gemma":[0.997754,0.0005533556,0.000224842,0.0006518399,0.0001771338,0.0006388657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002175342,0.0007349966,0.004178539,0.001199726,0.00005272818,0.003450118,0.002438557,0.0001171364,0.9838979,0.0000277722,0.003389172,0.0002957941],"study_design_scores_gemma":[0.002487078,0.003370102,0.01284952,0.0001834943,0.0004049623,0.00006339199,0.0004478722,0.0003085362,0.969575,0.00007620056,0.01007521,0.0001586532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883652,0.003370577,0.0001794019,0.0001920482,0.0003780339,0.0009176394,0.0001432388,0.00006687221,0.006387031],"genre_scores_gemma":[0.9948239,0.0005433525,0.001104933,0.001949638,0.0001349063,0.00003361385,0.00006184253,0.0001336352,0.001214192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01432295,"threshold_uncertainty_score":0.9997131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00719953472919734,"score_gpt":0.252003159666653,"score_spread":0.2448036249374557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}