{"id":"W4404730089","doi":"10.1002/1878-0261.13770","title":"Loss of <i>SETD2</i> in wild‐type <i>VHL</i> clear cell renal cell carcinoma sensitizes cells to <scp>STF</scp> ‐62247 and leads to <scp>DNA</scp> damage, cell cycle arrest, and cell death characteristic of pyroptosis","year":2024,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"Canadian Cancer Society Research Institute; New Brunswick Innovation Foundation; Fondation de la recherche en santé du Nouveau-Brunswick; Cancer Research Institute","keywords":"Clear cell renal cell carcinoma; Cell cycle; Biology; Cancer research; Cell cycle checkpoint; Chromatin; DNA repair; Histone; DNA damage; Molecular biology; Cell; Gene; Genetics; DNA; Renal cell carcinoma; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001049196,0.0003248373,0.0002339207,0.0001923999,0.0001532913,0.0002995504,0.0002670883,0.0002901996,0.00147799],"category_scores_gemma":[0.00009244326,0.0001459364,0.0003461813,0.0001904015,0.0002742888,0.0001538196,0.0001430228,0.0005825154,0.0004564523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000426061,"about_ca_system_score_gemma":0.000230461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008792786,"about_ca_topic_score_gemma":0.001346208,"domain_scores_codex":[0.9998178,0.00002684157,0.00002612138,0.00003354231,0.00006428007,0.00003148809],"domain_scores_gemma":[0.9998968,0.00002222561,0.00002659512,0.00001996203,0.000006017814,0.00002851347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004867285,0.00002935403,0.0001902324,0.00001442043,0.000005910518,0.00004797943,0.000005883877,0.00004118264,0.99915,0.00006323478,0.00002163463,0.0003813958],"study_design_scores_gemma":[0.00001124629,0.0001321211,0.002363339,0.000001382786,0.000009437686,0.0002590813,0.00001129927,0.0003796192,0.9958231,0.00001208437,0.0009943375,0.000002720416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961307,0.0005652785,0.001395988,0.00006733063,0.00002673002,0.00002579131,0.0006455135,0.00005782545,0.001084908],"genre_scores_gemma":[0.995934,0.0002720776,0.001126854,0.00003356253,0.000005477416,0.0000278089,0.001110781,0.00002079261,0.001468649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00147799,"threshold_uncertainty_score":0.004944384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00719953472919734,"score_gpt":0.252003159666653,"score_spread":0.2448036249374557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}