{"id":"W4404731599","doi":"10.1101/2024.11.25.24317569","title":"Beyond HER2 expression in breast cancer: Investigating alternative splicing profiles as a mechanism of resistance to anti-HER2 therapies","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Trastuzumab; Alternative splicing; Gene isoform; Breast cancer; RNA splicing; Cancer research; Biology; Receptor tyrosine kinase; Computational biology; Cancer; Bioinformatics; Medicine; Signal transduction; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004672474,0.0002234875,0.0003758264,0.0005774147,0.0001227968,0.0005441717,0.0001871018,0.0002616609,0.0006340807],"category_scores_gemma":[0.0004309184,0.0001014679,0.0002727614,0.0007713314,0.0002535008,0.0003434077,0.0001609696,0.0004119133,0.0002491793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002620154,"about_ca_system_score_gemma":0.0001641275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003243814,"about_ca_topic_score_gemma":0.0003851306,"domain_scores_codex":[0.9997813,0.00004308025,0.0000170133,0.00005459078,0.00007163337,0.00003239753],"domain_scores_gemma":[0.9997342,0.00007268872,0.00008232965,0.0000311669,0.00005692457,0.00002261782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004139355,0.00007480739,0.04069627,0.0002434624,0.00005736852,0.0003216507,0.0001730502,0.0005450355,0.9215818,0.000390948,0.0002296689,0.03527205],"study_design_scores_gemma":[0.0000310617,0.001256597,0.4166672,0.00009136353,0.0002889489,0.005791615,0.0005186045,0.008738787,0.5421274,0.001800594,0.02265091,0.00003690794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848863,0.008946946,0.004144484,0.0002037774,0.00001897751,0.0000246218,0.0005104493,0.00003545593,0.001228903],"genre_scores_gemma":[0.987201,0.007784087,0.002962711,0.0001923794,0.0000459536,0.00002525264,0.0008037306,0.00001916653,0.0009658408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006340807,"threshold_uncertainty_score":0.00247103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02634640374195375,"score_gpt":0.3330071045170884,"score_spread":0.3066607007751346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}