{"id":"W4404738773","doi":"10.1038/s41467-024-54684-2","title":"Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Allergic Rhinitis and Sensitization","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE Framework Programme; Action LIONS Vaincre le Cancer; European Academy of Allergy and Clinical Immunology; Fonds National de la Recherche Luxembourg; International Council for Canadian Studies; European Commission; Integrated BioBank of Luxembourg","keywords":"Venom; Allergy; Immunology; Immune system; Biology; Allergen immunotherapy; CD8; Immunotherapy; Allergen","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007187147,0.0002960164,0.0005526609,0.0005732685,0.0004924158,0.0007843658,0.0002689199,0.0005298415,0.001167509],"category_scores_gemma":[0.0009446987,0.0001617641,0.0005828231,0.0007031414,0.0002563059,0.0004669783,0.0008290048,0.0007815399,0.0002785563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002745931,"about_ca_system_score_gemma":0.0003440839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001233487,"about_ca_topic_score_gemma":0.0015809,"domain_scores_codex":[0.9995053,0.0001171717,0.00004997294,0.0001600614,0.00007885049,0.00008871336],"domain_scores_gemma":[0.9992336,0.0001250402,0.0002464213,0.0001168677,0.0001352509,0.0001428314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009265271,0.0002568221,0.9834157,0.0001289897,0.000302913,0.0004719321,0.0003740334,0.00008739324,0.00560056,0.0001273409,0.0007488226,0.007558864],"study_design_scores_gemma":[0.00001376445,0.0004944318,0.9949198,0.00003203804,0.0001692092,0.0007594969,0.0006300592,0.0004026912,0.000853905,0.0001805233,0.001530592,0.00001353845],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963612,0.001016465,0.0009786998,0.0000711391,0.00001720887,0.00002905511,0.001130146,0.00000831861,0.0003878485],"genre_scores_gemma":[0.9974433,0.000359314,0.0005179414,0.00006777055,0.00003690624,0.00004391214,0.001292659,0.000006765531,0.0002315019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001233487,"threshold_uncertainty_score":0.003905714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1208779484264187,"score_gpt":0.3092554654561889,"score_spread":0.1883775170297703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}