{"id":"W4404749043","doi":"10.1016/j.immuni.2024.10.014","title":"Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling","year":2024,"lang":"en","type":"article","venue":"Immunity","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill Genome Centre","funders":"Vermont Agency of Natural Resources; National Institutes of Health; New South Wales Government; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Glenn Foundation for Medical Research; Honjo International Scholarship Foundation; Universidad de Antioquia; National Health and Medical Research Council; SCOR Corporate Foundation for Science; Ministério da Ciência, Tecnologia e Inovação; Institut National de la Santé et de la Recherche Médicale; Fondation pour la Recherche Médicale; National Institute on Handicapped Research; Université Paris-Saclay; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Australian Government; Agence Nationale de la Recherche; Tasmanian Department of Health; Rockefeller University; Research England; Icahn School of Medicine at Mount Sinai; Ministerio de Ciencia, Tecnología, Conocimiento e Innovación; Diabetes UK; Ministry of Health, Labour and Welfare; St. Giles Foundation; National Center for Advancing Translational Sciences; Medical Research Council; Leona M. and Harry B. Helmsley Charitable Trust; Immune Deficiency Foundation; Ministerio de Ciencia, Tecnología e Innovación","keywords":"Biology; Antibody; Signal transduction; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003462602,0.001303187,0.0006609329,0.001212418,0.0003845053,0.0007978475,0.0004115961,0.00127755,0.003572347],"category_scores_gemma":[0.0005466848,0.0003852212,0.0003624245,0.0003207413,0.001119537,0.0004639257,0.0004716885,0.0009844407,0.0004580321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003047783,"about_ca_system_score_gemma":0.0003530762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006337049,"about_ca_topic_score_gemma":0.0004188771,"domain_scores_codex":[0.9997149,0.0000469075,0.00002040475,0.0001286026,0.00004147484,0.00004775031],"domain_scores_gemma":[0.9997608,0.00003427329,0.0001058054,0.00003466156,0.00001874725,0.00004567295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004526259,0.000519199,0.03334153,0.0004061975,0.000250958,0.006174876,0.0003224427,0.0007534479,0.9099037,0.003049432,0.002936723,0.03781513],"study_design_scores_gemma":[0.001176981,0.006761806,0.3771677,0.0004839369,0.001417635,0.1179764,0.001214157,0.005522232,0.4420592,0.01060005,0.03542809,0.0001918638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883399,0.002596862,0.004066584,0.0004996532,0.00007666626,0.00004784178,0.001185531,0.0002937503,0.00289316],"genre_scores_gemma":[0.9942139,0.001024008,0.001660154,0.0002638828,0.00002973629,0.00005107817,0.0007354036,0.00004611404,0.001975737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003572347,"threshold_uncertainty_score":0.01195067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02729393616749533,"score_gpt":0.3143739235201,"score_spread":0.2870799873526047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}