{"id":"W4404749043","doi":"10.1016/j.immuni.2024.10.014","title":"Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling","year":2024,"lang":"en","type":"article","venue":"Immunity","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill Genome Centre","funders":"Vermont Agency of Natural Resources; National Institutes of Health; New South Wales Government; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Glenn Foundation for Medical Research; Honjo International Scholarship Foundation; Universidad de Antioquia; National Health and Medical Research Council; SCOR Corporate Foundation for Science; Ministério da Ciência, Tecnologia e Inovação; Institut National de la Santé et de la Recherche Médicale; Fondation pour la Recherche Médicale; National Institute on Handicapped Research; Université Paris-Saclay; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Australian Government; Agence Nationale de la Recherche; Tasmanian Department of Health; Rockefeller University; Research England; Icahn School of Medicine at Mount Sinai; Ministerio de Ciencia, Tecnología, Conocimiento e Innovación; Diabetes UK; Ministry of Health, Labour and Welfare; St. Giles Foundation; National Center for Advancing Translational Sciences; Medical Research Council; Leona M. and Harry B. Helmsley Charitable Trust; Immune Deficiency Foundation; Ministerio de Ciencia, Tecnología e Innovación","keywords":"Biology; Antibody; Signal transduction; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008484927,0.00008695079,0.0001813663,0.0002424077,0.00004113251,0.00001468542,0.00003973697,0.00004861733,0.00002386245],"category_scores_gemma":[0.00002328377,0.00007630118,0.00002294022,0.0002320758,0.00009391367,0.00004072753,0.00004167787,0.0001547755,9.162138e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007956133,"about_ca_system_score_gemma":0.0001756935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008205459,"about_ca_topic_score_gemma":0.000304751,"domain_scores_codex":[0.999275,0.00009146128,0.0002815447,0.0001304553,0.00009431127,0.0001272636],"domain_scores_gemma":[0.9996634,0.0001546742,0.00002815967,0.0001112512,0.00001705617,0.00002542133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001219407,0.0001005417,0.009934144,0.0003257106,0.00003178442,0.00003226251,0.01083271,0.000001598775,0.967063,0.000003623729,0.000009902987,0.01044532],"study_design_scores_gemma":[0.001653951,0.0001659267,0.5692101,0.00127549,0.0000196832,0.00001831449,0.003571581,0.0000943624,0.4230693,0.00001699218,0.0007738776,0.0001304345],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892603,0.01022876,0.00001585831,0.00008127568,0.0000689993,0.0001889926,0.00000529004,0.00001520135,0.0001353264],"genre_scores_gemma":[0.9990697,0.0003219917,0.0004303058,0.00004922913,0.000005863324,0.000005029676,0.000006584247,0.000008417674,0.0001028613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.559276,"threshold_uncertainty_score":0.3111472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02729393616749533,"score_gpt":0.3143739235201,"score_spread":0.2870799873526047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}