{"id":"W4404749160","doi":"10.1158/1078-0432.ccr-24-2061","title":"Framework for the Pathology Workup of Metastatic Castration-Resistant Prostate Cancer Biopsies","year":2024,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"DOD Prostate Cancer Research Program; National Cancer Institute; Genentech; National Institutes of Health; Astellas Pharma; Institute for Prostate Cancer Research; Celgene; U.S. Department of Defense; Sanofi; Prostate Cancer Foundation; Eli Lilly and Company; Bristol-Myers Squibb; Pfizer; V Foundation for Cancer Research; Intuitive Surgical; Doris Duke Charitable Foundation; Amgen","keywords":"Prostate cancer; Neuroendocrine differentiation; Medicine; Adenocarcinoma; Pathology; Context (archaeology); Enzalutamide; Prostate; Androgen deprivation therapy; Androgen receptor; Chromogranin A; Lineage markers; Neuroendocrine tumors; Synaptophysin; Cancer; Immunohistochemistry; Cancer research; Phenotype; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.005703399,0.0005094217,0.002792601,0.0004678559,0.0003048232,0.0001207505,0.0006610911,0.000573149,0.0004772676],"category_scores_gemma":[0.002294423,0.000252072,0.001370893,0.001795811,0.00214324,0.0000522564,0.0003480571,0.003482211,0.00008342927],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005666249,"about_ca_system_score_gemma":0.008394221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003684351,"about_ca_topic_score_gemma":0.0002332983,"domain_scores_codex":[0.9935956,0.001008424,0.001922681,0.001108394,0.001243256,0.001121638],"domain_scores_gemma":[0.9862815,0.01074692,0.0003845531,0.001083361,0.001155849,0.0003478142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001593065,0.0002759215,0.00009293391,0.05960048,0.002928083,0.0002779364,0.0002009431,0.000001384468,0.000004519267,0.001388177,0.01467168,0.9189649],"study_design_scores_gemma":[0.001054634,0.001283652,0.00006935836,0.03769141,0.004806771,0.00001888663,0.0002333693,0.00002077395,0.00001439143,0.002591655,0.9519604,0.0002546452],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001086604,0.9844882,0.00002992803,0.004871738,0.001256299,0.007316018,0.001784558,0.0000416802,0.000102857],"genre_scores_gemma":[0.0001576677,0.9768903,0.0006441614,0.00007334536,0.001375359,0.01220991,0.0001535345,0.0001557783,0.008339934],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9372888,"threshold_uncertainty_score":0.9999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6165722208737369,"score_gpt":0.6663704275781906,"score_spread":0.04979820670445378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}