{"id":"W4404749160","doi":"10.1158/1078-0432.ccr-24-2061","title":"Framework for the Pathology Workup of Metastatic Castration-Resistant Prostate Cancer Biopsies","year":2024,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"DOD Prostate Cancer Research Program; National Cancer Institute; Genentech; National Institutes of Health; Astellas Pharma; Institute for Prostate Cancer Research; Celgene; U.S. Department of Defense; Sanofi; Prostate Cancer Foundation; Eli Lilly and Company; Bristol-Myers Squibb; Pfizer; V Foundation for Cancer Research; Intuitive Surgical; Doris Duke Charitable Foundation; Amgen","keywords":"Prostate cancer; Neuroendocrine differentiation; Medicine; Adenocarcinoma; Pathology; Context (archaeology); Enzalutamide; Prostate; Androgen deprivation therapy; Androgen receptor; Chromogranin A; Lineage markers; Neuroendocrine tumors; Synaptophysin; Cancer; Immunohistochemistry; Cancer research; Phenotype; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004725112,0.001683115,0.001978556,0.005331525,0.0005001251,0.002204531,0.002622815,0.00247277,0.004391659],"category_scores_gemma":[0.005331378,0.0005869256,0.001541406,0.002354739,0.001480429,0.002338282,0.001387099,0.004257432,0.003734061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002813474,"about_ca_system_score_gemma":0.005475266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003939235,"about_ca_topic_score_gemma":0.005261284,"domain_scores_codex":[0.9980628,0.000665642,0.0003883369,0.0002312482,0.0005663536,0.00008566943],"domain_scores_gemma":[0.9963477,0.001282393,0.000499044,0.0001485614,0.001547865,0.0001743467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001010599,0.00008555932,0.0005341597,0.03249985,0.0001912586,0.0004462918,0.0001728908,0.0007855339,0.001133007,0.02317528,0.08755259,0.8533224],"study_design_scores_gemma":[0.00002769951,0.0000895052,0.001770989,0.03257512,0.0002737078,0.00211457,0.0001335516,0.0003092578,0.0003648002,0.00831733,0.9539792,0.00004433259],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001592226,0.9864215,0.002994387,0.004764962,0.001476334,0.0001216089,0.0001800253,0.00006696431,0.003815121],"genre_scores_gemma":[0.003435357,0.9762215,0.01196159,0.004110419,0.001555281,0.0002466597,0.0004947053,0.00002233201,0.0019521],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005331525,"threshold_uncertainty_score":0.02498907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6165722208737369,"score_gpt":0.6663704275781906,"score_spread":0.04979820670445378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}