{"id":"W4404778918","doi":"10.1016/j.it.2024.11.004","title":"How do autoimmune CD4+ T cells handle exhaustion?","year":2024,"lang":"en","type":"article","venue":"Trends in Immunology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Wellcome Trust","keywords":"Immunology; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182093,0.0001711789,0.0002191925,0.0006355987,0.00008001201,0.0001552492,0.0002459227,0.000181183,0.0007321315],"category_scores_gemma":[0.00005717885,0.0001623056,0.00009047357,0.0008993551,0.0002351628,0.000214284,0.00009336439,0.0004395094,0.0005866999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008655998,"about_ca_system_score_gemma":0.00004384232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001959092,"about_ca_topic_score_gemma":0.000007933596,"domain_scores_codex":[0.998632,0.0001057391,0.000202298,0.0004976102,0.0001098786,0.000452535],"domain_scores_gemma":[0.999375,0.0001588179,0.00003467965,0.0003868057,0.000008400995,0.00003632119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002504114,0.00006769947,0.00008338295,0.00001407062,0.00001204954,0.0004178263,0.000724987,0.00001831025,0.7809955,0.09033553,0.00155531,0.1257503],"study_design_scores_gemma":[0.0007045886,0.0001348055,0.01029636,0.00007319076,0.00001478626,0.0003152699,0.0001013123,0.0004215628,0.6028,0.001072967,0.3837556,0.0003095045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9359387,0.02061201,0.0001718886,0.004739896,0.007248749,0.0001486568,0.00004085157,0.000591918,0.03050739],"genre_scores_gemma":[0.9502043,0.0003989295,0.00005601929,0.00009164904,0.00008432919,0.00003022377,0.000005056217,0.00002689558,0.04910264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3822003,"threshold_uncertainty_score":0.8016326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02532545076398532,"score_gpt":0.2731360282524363,"score_spread":0.247810577488451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}