{"id":"W4404779304","doi":"10.21203/rs.3.rs-5485352/v1","title":"No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Long-Term Effects of COVID-19","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Vaccination; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Immune system; Virology; 2019-20 coronavirus outbreak; Medicine; Herd immunity; Immunology; Outbreak; Internal medicine; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001334616,0.0002553108,0.0006043343,0.000228887,0.0004467836,0.0006762974,0.0004609773,0.001223561,0.00551526],"category_scores_gemma":[0.005677192,0.0001997421,0.0006261399,0.000231457,0.0004562461,0.0006855652,0.0006247682,0.0009682794,0.0006014167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084315,"about_ca_system_score_gemma":0.0004287497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001433435,"about_ca_topic_score_gemma":0.001202031,"domain_scores_codex":[0.9993488,0.0001748697,0.0000335705,0.0001720739,0.00006353882,0.0002071694],"domain_scores_gemma":[0.9968449,0.001019881,0.0006814215,0.000618423,0.000231247,0.0006042062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0428646,0.00136514,0.8750883,0.0006468691,0.001267707,0.00171731,0.002209512,0.0003424429,0.02689396,0.0005625257,0.001643091,0.04539846],"study_design_scores_gemma":[0.00007485344,0.003432663,0.9936445,0.00004103148,0.0002013044,0.0002556053,0.0003876808,0.00007964763,0.0005728535,0.0003815936,0.00091705,0.00001120804],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971703,0.0008508393,0.00008357388,0.0002165878,0.00005369668,0.00001202167,0.0002557785,0.000005123657,0.001352105],"genre_scores_gemma":[0.9985473,0.0001750242,0.0000340658,0.0001861009,0.00004539324,0.00001552718,0.0002371179,0.000003707177,0.0007558407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00551526,"threshold_uncertainty_score":0.01845032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1109442480932638,"score_gpt":0.4836980459319694,"score_spread":0.3727537978387057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}