{"id":"W4404780893","doi":"10.1101/2024.11.26.625504","title":"In mouse and in vitro models, bowel preparation promotes pathogen colonization, translocation and exacerbation of inflammation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; McMaster University; University of British Columbia","funders":"","keywords":"Colonization; Chromosomal translocation; Pathogen; Bacterial translocation; Colonoscopy; Bowel preparation; Microbiology; Biology; Medicine; Colorectal cancer; Internal medicine; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005818288,0.0009012445,0.0004213734,0.0005775424,0.0002094727,0.0007482626,0.000211525,0.0005993967,0.003084762],"category_scores_gemma":[0.0002835688,0.0002601991,0.0006527282,0.0002219903,0.000507192,0.0004089499,0.0004118347,0.001371734,0.0008954325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002525298,"about_ca_system_score_gemma":0.0002488282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003378667,"about_ca_topic_score_gemma":0.0004721741,"domain_scores_codex":[0.9995121,0.0001649991,0.00004065225,0.00009357667,0.0001068021,0.00008197544],"domain_scores_gemma":[0.9994624,0.00009893171,0.0001890805,0.0001044365,0.00003586286,0.0001093152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002619585,0.00009004231,0.0003666091,0.0001072919,0.00001269787,0.0001067274,0.00002557688,0.00008132737,0.9974727,0.000139246,0.000166066,0.001169644],"study_design_scores_gemma":[0.00003286877,0.001631877,0.004715283,0.00004990841,0.00004871807,0.0004523728,0.00008287674,0.0007486622,0.9874651,0.0001979167,0.004563752,0.0000107109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.953696,0.009889149,0.02564613,0.00126266,0.0006222401,0.0001329382,0.001639471,0.0006268466,0.006484634],"genre_scores_gemma":[0.9787521,0.004509802,0.007541188,0.000406218,0.00009683237,0.0001125445,0.001248491,0.0001070029,0.007225882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003084762,"threshold_uncertainty_score":0.01031953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008474365900620541,"score_gpt":0.2249866238421979,"score_spread":0.2165122579415774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}