{"id":"W4404788147","doi":"10.1101/2024.11.25.24317794","title":"Multi-ancestry genome-wide association study reveals novel genetic signals for lung function decline","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; NIHR Leicester Biomedical Research Centre; National Institutes of Health; National Institute of Nursing Research; University of Leicester; National Institute for Health and Care Research; UK Research and Innovation; Broad Institute; Wellcome Trust","keywords":"Genome-wide association study; Lung function; Association (psychology); Genetic association; Biology; Function (biology); Evolutionary biology; Computational biology; Genome; Genetic genealogy; Genetics; Medicine; Single-nucleotide polymorphism; Genotype; Lung; Environmental health; Internal medicine; Psychology; Gene; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002625502,0.0005372797,0.0009595997,0.001268298,0.0006757202,0.001349572,0.0007193153,0.0008519134,0.002239739],"category_scores_gemma":[0.004302482,0.0003113867,0.00213188,0.002644027,0.0004930471,0.0004322244,0.0009469981,0.000885975,0.0002199037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002418751,"about_ca_system_score_gemma":0.000424155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004323752,"about_ca_topic_score_gemma":0.005510131,"domain_scores_codex":[0.9980493,0.0006901223,0.0001778767,0.0006975394,0.0002343505,0.0001508782],"domain_scores_gemma":[0.9969807,0.001128552,0.0007481934,0.0007324726,0.0002238402,0.0001862257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001229777,0.00007262643,0.9709802,0.0001787555,0.009291078,0.0005181633,0.0001905686,0.0009620737,0.007606704,0.0003383579,0.0004862142,0.008145395],"study_design_scores_gemma":[0.00007864334,0.0001083378,0.9908363,0.000036802,0.004488895,0.0003782326,0.00009531149,0.001837324,0.0007785725,0.0006828025,0.0006643337,0.00001452777],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896166,0.004857244,0.003086935,0.0003412642,0.0000438353,0.00002044463,0.001197167,0.00006468115,0.0007718045],"genre_scores_gemma":[0.9982423,0.0004412165,0.000668043,0.00007850909,0.00003186301,0.0000119367,0.0003695388,0.00001066286,0.0001460696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004323752,"threshold_uncertainty_score":0.01388514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04026595672453639,"score_gpt":0.3235668043251265,"score_spread":0.2833008476005902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}