{"id":"W4404789710","doi":"10.1021/acs.est.4c07236","title":"Dose-Related Mutagenic and Clastogenic Effects of Benzo[ <i>b</i> ]fluoranthene in Mouse Somatic Tissues Detected by Duplex Sequencing and the Micronucleus Assay","year":2024,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Health Canada; University of Ottawa","funders":"National Institute of Environmental Health Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canada Research Chairs; Health Canada; University of Ottawa; Burroughs Wellcome Fund","keywords":"Clastogen; Fluoranthene; Somatic cell; Micronucleus test; Micronucleus; Duplex (building); Biology; Genetics; Molecular biology; Toxicology; Chemistry; Gene; Toxicity; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002452084,0.0004096715,0.0002027216,0.0007303172,0.0001228977,0.0001377722,0.0001517386,0.0004407628,0.00129546],"category_scores_gemma":[0.0001190012,0.0002063095,0.0002926122,0.0002645946,0.0001899672,0.0001351432,0.0001638059,0.0003959821,0.0001841364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001721013,"about_ca_system_score_gemma":0.000145745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007716968,"about_ca_topic_score_gemma":0.001265504,"domain_scores_codex":[0.9997258,0.00005165283,0.00003289584,0.00008281845,0.00006083765,0.00004610152],"domain_scores_gemma":[0.9997784,0.00003919021,0.00007811375,0.00002443416,0.00003497636,0.00004489581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001026139,0.00001976657,0.0003392148,0.00001326821,0.000004898247,0.000008179459,0.000008642123,0.00005064432,0.9988999,0.00001283988,0.00000786598,0.000532104],"study_design_scores_gemma":[0.000007673396,0.001076181,0.009694614,0.000003287699,0.00002043536,0.00006058853,0.00001459351,0.0002940671,0.9884626,0.00002403394,0.0003376766,0.000004304702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949529,0.001125648,0.002478974,0.00002998304,0.00001019047,0.00003897822,0.0005399947,0.00006226551,0.0007611323],"genre_scores_gemma":[0.9890891,0.00124755,0.003726741,0.00006747432,0.000008061286,0.0001382074,0.001080981,0.00002672353,0.004615219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129546,"threshold_uncertainty_score":0.004333675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001922252881304339,"score_gpt":0.1880130236890934,"score_spread":0.186090770807789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}