{"id":"W4404789710","doi":"10.1021/acs.est.4c07236","title":"Dose-Related Mutagenic and Clastogenic Effects of Benzo[ <i>b</i> ]fluoranthene in Mouse Somatic Tissues Detected by Duplex Sequencing and the Micronucleus Assay","year":2024,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Health Canada; University of Ottawa","funders":"National Institute of Environmental Health Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canada Research Chairs; Health Canada; University of Ottawa; Burroughs Wellcome Fund","keywords":"Clastogen; Fluoranthene; Somatic cell; Micronucleus test; Micronucleus; Duplex (building); Biology; Genetics; Molecular biology; Toxicology; Chemistry; Gene; Toxicity; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002788033,0.0001313945,0.0001523387,0.0001358683,0.00009256473,0.00002827779,0.0002247496,0.0001433888,0.000006457415],"category_scores_gemma":[0.00008432612,0.000104581,0.00002752882,0.0002623017,0.002130793,0.000008598843,0.0003261264,0.0001278652,0.000003211286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007935469,"about_ca_system_score_gemma":0.00004129947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005019325,"about_ca_topic_score_gemma":0.00002946419,"domain_scores_codex":[0.9990374,0.00003236801,0.0001969016,0.0003905216,0.00009811382,0.0002446475],"domain_scores_gemma":[0.9996147,0.00005832879,0.00005154803,0.0002310816,0.000003013077,0.00004129171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001402588,0.00002105599,0.0007692832,0.00001691799,0.00001722777,0.000006826501,0.0001524352,0.00001851314,0.9889564,0.00009189241,0.00001103654,0.009924402],"study_design_scores_gemma":[0.0007593973,0.0002257827,0.0008712884,0.00002499266,0.00002505316,0.00006428647,0.0001826922,0.001286564,0.9956294,0.0003066608,0.0004949255,0.0001290128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796985,0.01960338,0.0001115513,0.0001924493,0.00006129414,0.0002778572,0.000020524,0.00001787471,0.00001658189],"genre_scores_gemma":[0.9964485,0.003222788,0.0001792805,0.00003882584,0.000007508653,0.00002410169,0.000006662807,0.00001453569,0.00005778335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01675003,"threshold_uncertainty_score":0.7850996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001922252881304339,"score_gpt":0.1880130236890934,"score_spread":0.186090770807789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}