{"id":"W4404792126","doi":"10.1038/s41467-024-54105-4","title":"Hybrid adaptation is hampered by Haldane’s sieve","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Natural Sciences and Engineering Research Council of Canada; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; Génome Québec","keywords":"Hybrid; Biology; Loss of heterozygosity; Genetics; Adaptation (eye); Dominance (genetics); Gene; Fixation (population genetics); Genetic architecture; Evolutionary biology; Phenotype; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002056441,0.0003441372,0.0003497466,0.0003332492,0.0002865897,0.0005687396,0.0003660249,0.0004215912,0.001500078],"category_scores_gemma":[0.000478463,0.0002734593,0.0003814548,0.0001683957,0.0004747246,0.000323603,0.0009791497,0.0007832801,0.0003541872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002607474,"about_ca_system_score_gemma":0.0001865675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003306558,"about_ca_topic_score_gemma":0.0006703266,"domain_scores_codex":[0.9998389,0.00002610106,0.00001393443,0.00004146697,0.00005207277,0.00002743629],"domain_scores_gemma":[0.9995889,0.0001193244,0.0001241916,0.0000724598,0.00002486783,0.0000702251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006258822,0.00001027666,0.0009473382,0.00002657671,0.00001735162,0.0002537544,0.00006654931,0.0003720752,0.9936134,0.0008476083,0.00005682685,0.0037257],"study_design_scores_gemma":[0.00002138477,0.0002893223,0.02067351,0.00001664987,0.00003682858,0.002305672,0.0001900576,0.006409832,0.9592476,0.001557807,0.009207836,0.00004343397],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914666,0.0004530604,0.00544083,0.00009354432,0.00002184257,0.00000892902,0.00007628692,0.0001450328,0.002293848],"genre_scores_gemma":[0.9958767,0.000170092,0.002167312,0.00005844197,0.000003461042,0.00001509246,0.00008775932,0.00005618187,0.001565072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001500078,"threshold_uncertainty_score":0.005018234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036675601621939,"score_gpt":0.2864676795676031,"score_spread":0.2761009235513837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}