{"id":"W4404799289","doi":"10.1016/s1470-2045(24)00508-4","title":"Safety and activity of CTX130, a CD70-targeted allogeneic CRISPR-Cas9-engineered CAR T-cell therapy, in patients with relapsed or refractory T-cell malignancies (COBALT-LYM): a single-arm, open-label, phase 1, dose-escalation study","year":2024,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"CRISPR; Refractory (planetary science); Open label; Medicine; Cancer research; Internal medicine; Adverse effect; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007015831,0.0005579798,0.0008658387,0.000202456,0.0002309148,0.0004906871,0.0003789087,0.0006074168,0.001346532],"category_scores_gemma":[0.0002706319,0.0002435749,0.0006261909,0.0001651558,0.0005631399,0.000445657,0.0001759407,0.001328754,0.000319604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005438068,"about_ca_system_score_gemma":0.0007318719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007200269,"about_ca_topic_score_gemma":0.001496718,"domain_scores_codex":[0.9997831,0.00008293481,0.00001200955,0.00004317905,0.00003191883,0.00004680234],"domain_scores_gemma":[0.9997415,0.00003999783,0.00006807937,0.00002539417,0.00001531071,0.0001097914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2950013,0.0822172,0.01497386,0.0007629247,0.001089286,0.0004342972,0.0005862701,0.005896336,0.4252857,0.0002971172,0.003631805,0.169824],"study_design_scores_gemma":[0.07476041,0.8545927,0.02399805,0.00002297075,0.000436002,0.0005760411,0.0000934763,0.00246543,0.04035971,0.0001430614,0.002512889,0.00003936574],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984167,0.0005030598,0.0002404097,0.00004884164,0.00001501063,0.0002524586,0.0001554807,0.00003250463,0.0003356051],"genre_scores_gemma":[0.9982387,0.0002936172,0.0003269807,0.0001244416,0.00002451389,0.0002010307,0.0003135851,0.00001047738,0.0004666416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346532,"threshold_uncertainty_score":0.004504561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0810241588147585,"score_gpt":0.3709479855397072,"score_spread":0.2899238267249487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}