{"id":"W4404809214","doi":"10.1126/science.adj7615","title":"PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance","year":2024,"lang":"en","type":"article","venue":"Science","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; SickKids Foundation; University of Calgary; Hospital for Sick Children","funders":"","keywords":"Mechanosensitive channels; Stem cell; Cell biology; Organoid; Mechanosensation; Cell fate determination; Biology; Mechanotransduction; Sense (electronics); Niche; Chemistry; Ion channel; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001224809,0.0001458918,0.0001479856,0.0001493565,0.0001571715,0.0003833448,0.0001307313,0.0001877922,0.0005273608],"category_scores_gemma":[0.0001362504,0.0001252341,0.00009932004,0.00009698334,0.0003082017,0.0002824754,0.0002359848,0.0003247227,0.0001447278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001832488,"about_ca_system_score_gemma":0.000242485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00026851,"about_ca_topic_score_gemma":0.0003612874,"domain_scores_codex":[0.9998897,0.00001312224,0.000009658538,0.00002040019,0.00004261019,0.00002456788],"domain_scores_gemma":[0.9998885,0.0000142633,0.00004619085,0.000008407695,0.00001659347,0.00002595264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003782997,0.000004475852,0.0009953007,0.00001871852,0.000001467101,0.00007141932,0.00001742081,0.00005665261,0.9963936,0.0004222882,0.00002415664,0.001956749],"study_design_scores_gemma":[0.00001348562,0.0001208476,0.05118147,0.00001412783,0.00001145367,0.0004204196,0.0001407309,0.002297213,0.941853,0.0007679184,0.003171291,0.00000809865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840588,0.001688414,0.01197335,0.0001959929,0.00001656782,0.00001716115,0.0001460163,0.00009602486,0.001807691],"genre_scores_gemma":[0.9972265,0.0005077126,0.00150193,0.00001872875,0.000004985385,0.00001022769,0.00005919193,0.000006415919,0.0006643185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005273608,"threshold_uncertainty_score":0.001764178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963935923933097,"score_gpt":0.2921648754934561,"score_spread":0.2725255162541251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}