{"id":"W4404821239","doi":"10.3390/vaccines12121344","title":"Protein Expression Platforms and the Challenges of Viral Antigen Production","year":2024,"lang":"en","type":"review","venue":"Vaccines","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Public Health Agency of Canada; University of Manitoba; Canadian Food Inspection Agency","funders":"","keywords":"Context (archaeology); Immunogenicity; Biopharmaceutical; Biology; Computational biology; Antigen; Protein expression; Protein subunit; Production (economics); Biotechnology; Computer science; Virology; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008430809,0.0006199787,0.0009863705,0.00123621,0.000268448,0.001587314,0.000674205,0.001079052,0.001592845],"category_scores_gemma":[0.0006238998,0.0003935749,0.0004764795,0.001336968,0.0005477935,0.001570772,0.0006169915,0.002559807,0.002373945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007164136,"about_ca_system_score_gemma":0.0006815374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000982722,"about_ca_topic_score_gemma":0.00070668,"domain_scores_codex":[0.9995918,0.0000661344,0.00003891194,0.00006552313,0.0002074655,0.00003021231],"domain_scores_gemma":[0.999746,0.0001428963,0.00003111625,0.00001189515,0.00005502791,0.00001303619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000755994,0.0000833511,0.0001792508,0.01857876,0.0000542865,0.0003303043,0.0001704017,0.001119824,0.0437615,0.02399315,0.01641889,0.8952347],"study_design_scores_gemma":[0.000006686132,0.0001206452,0.0003663413,0.001453201,0.00004080901,0.0009809994,0.00006349078,0.000197922,0.008663516,0.00252788,0.9855579,0.00002079924],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006233685,0.9939315,0.001535387,0.0003575313,0.0002207161,0.00001134091,0.00003951038,0.00002653856,0.003254179],"genre_scores_gemma":[0.002294921,0.9935851,0.001743129,0.0002090496,0.0001252454,0.0000250273,0.00008812896,0.000009282978,0.001920198],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001592845,"threshold_uncertainty_score":0.005328596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02421022089177159,"score_gpt":0.3049808473261615,"score_spread":0.2807706264343899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}