{"id":"W4404821239","doi":"10.3390/vaccines12121344","title":"Protein Expression Platforms and the Challenges of Viral Antigen Production","year":2024,"lang":"en","type":"review","venue":"Vaccines","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Public Health Agency of Canada; University of Manitoba; Canadian Food Inspection Agency","funders":"","keywords":"Context (archaeology); Immunogenicity; Biopharmaceutical; Biology; Computational biology; Antigen; Protein expression; Protein subunit; Production (economics); Biotechnology; Computer science; Virology; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001748294,0.000265409,0.0005170908,0.00006331061,0.00007451258,0.00002329841,0.0001549714,0.0002262812,0.000006063515],"category_scores_gemma":[0.00008275165,0.0001266822,0.0002783597,0.00006857129,0.00005928505,0.000004599174,0.0002286006,0.0001261067,0.000006167484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004342324,"about_ca_system_score_gemma":0.00005744025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006643566,"about_ca_topic_score_gemma":0.000004291394,"domain_scores_codex":[0.9989807,0.00006182754,0.0003167196,0.0004146033,0.00009537016,0.0001308037],"domain_scores_gemma":[0.9993157,0.000009017448,0.0002015695,0.0003921635,0.00004467083,0.0000369219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004007013,0.0001480693,0.000007940374,0.0471436,0.0006440817,0.00000466367,0.0001717913,0.000003339309,0.0139208,0.002542028,0.0177869,0.9172261],"study_design_scores_gemma":[0.0003710135,0.000211438,0.000006369759,0.009178495,0.0003670923,0.00004757623,0.00004117126,0.000001921319,0.01077687,0.001559731,0.9771194,0.0003189235],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005460902,0.9930289,0.000003808581,0.00005347237,0.0004014207,0.0008312705,0.00001829624,0.00001717441,0.0001847098],"genre_scores_gemma":[0.005588682,0.9927229,0.0000222551,0.000006532617,0.000764133,0.0002561641,0.0000382602,0.0000373513,0.0005636744],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9593325,"threshold_uncertainty_score":0.5165952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02421022089177159,"score_gpt":0.3049808473261615,"score_spread":0.2807706264343899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}