{"id":"W4404822470","doi":"10.1080/19420862.2024.2435476","title":"Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery","year":2024,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"OmniActive Health Technologies (Canada)","funders":"","keywords":"Antibody; Epitope; Immunogenicity; Heavy chain; Single-domain antibody; Immunoglobulin light chain; Biology; Transgene; Antigen; Immune system; Computational biology; Ex vivo; Genetically modified mouse; Immunology; In vivo; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003262839,0.0002628322,0.0004791781,0.0002785906,0.0001392275,0.0001084577,0.0001302294,0.00008923153,0.0001552034],"category_scores_gemma":[0.00001368961,0.0001701433,0.0002191717,0.0003609943,0.0002283794,0.0001565626,0.00003233666,0.0003601354,0.00002780823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006552496,"about_ca_system_score_gemma":0.0002646441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002624673,"about_ca_topic_score_gemma":0.0006611804,"domain_scores_codex":[0.9981881,0.00005573417,0.0003191428,0.000475642,0.0003955577,0.0005658002],"domain_scores_gemma":[0.9993252,0.0002050572,0.00002444432,0.0002623131,0.0000653141,0.0001177061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01764604,0.001953657,0.2480506,0.01172802,0.001907345,0.001112003,0.008049346,0.00002459034,0.5925345,0.09262489,0.001620815,0.02274826],"study_design_scores_gemma":[0.02087854,0.01248335,0.6505154,0.00655461,0.0008914721,0.001037108,0.002705699,0.006644086,0.03948969,0.01516944,0.2411621,0.002468503],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842464,0.004876776,0.0005936507,0.007092424,0.0001205476,0.00113901,0.0001072587,0.0001021641,0.001721813],"genre_scores_gemma":[0.9878811,0.0005283072,0.0002704023,0.0003239923,0.0001968914,0.00007881623,0.0001982894,0.0000585396,0.01046371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5530448,"threshold_uncertainty_score":0.6938241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03386018991941837,"score_gpt":0.3679141465219078,"score_spread":0.3340539566024895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}