{"id":"W4404829280","doi":"10.3390/v16121844","title":"miR-24-3p Is Antiviral Against SARS-CoV-2 by Downregulating Critical Host Entry Factors","year":2024,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Viral entry; Furin; Biology; Coronavirus; Mechanism (biology); Effector; microRNA; Viral replication; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virus; Computational biology; Virology; Coronavirus disease 2019 (COVID-19); Gene; Immunology; Medicine; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000218532,0.000323791,0.0004051813,0.0002629222,0.0001597984,0.0002536694,0.0002075552,0.0002214287,0.00005647045],"category_scores_gemma":[0.0005743427,0.0002619768,0.0002207246,0.000507615,0.000316386,0.0003361833,0.0001456301,0.0005630399,0.0007381128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001316844,"about_ca_system_score_gemma":0.0002772544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003615898,"about_ca_topic_score_gemma":0.00001608017,"domain_scores_codex":[0.9975118,0.0000765057,0.0003747626,0.0006178928,0.0007098007,0.0007092412],"domain_scores_gemma":[0.9988457,0.0005562481,0.00002811158,0.0004158279,0.00008966936,0.00006446458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000810299,0.0001513236,0.03384791,0.0003161773,0.0001018733,0.0002633446,0.0005350473,1.135421e-8,0.9065139,0.0002626074,0.05521239,0.002714411],"study_design_scores_gemma":[0.0003334014,0.000121187,0.001076671,0.0002756767,0.00004538359,0.0000101179,0.0001843661,0.0002521813,0.6618688,0.00005443179,0.3355739,0.0002039419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867699,0.003184783,0.00007842485,0.000841705,0.0005545179,0.0002748329,0.0001895367,0.0003781194,0.007728151],"genre_scores_gemma":[0.9255748,0.0000189612,0.0000927019,0.07371315,0.0003974295,0.00001922856,0.00001128592,0.00007423255,0.00009825549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2803614,"threshold_uncertainty_score":0.9999833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07577240400773386,"score_gpt":0.3940609987098295,"score_spread":0.3182885947020956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}