{"id":"W4404829448","doi":"10.1002/advs.202407572","title":"Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science for Life Laboratory; Vetenskapsrådet; Université de Bordeaux; FP7 Ideas: European Research Council; Knut och Alice Wallenbergs Stiftelse; Novo Nordisk Fonden; Svenska Sällskapet för Medicinsk Forskning; Robert Bosch Stiftung; European Commission; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen; H2020 Society; Diamond Light Source; Novo Nordisk; European Federation of Pharmaceutical Industries and Associations; McGill University; Åke Wiberg Stiftelse","keywords":"Steatohepatitis; Dyslipidemia; Fatty liver; Steatosis; Drug discovery; Medicine; Fibrosis; Bioinformatics; Cancer research; Disease; Pathology; Pharmacology; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002311087,0.000162953,0.0001766962,0.0001445214,0.0001809251,0.00006963448,0.0001769625,0.0000236129,0.00002392918],"category_scores_gemma":[0.0002237501,0.0001135797,0.0001645146,0.0004936992,0.0001938044,0.0004500402,0.0001025517,0.00009170996,0.0000164628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083136,"about_ca_system_score_gemma":0.0002033467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004931687,"about_ca_topic_score_gemma":0.00001147689,"domain_scores_codex":[0.9984856,0.0000139015,0.000249726,0.0005751773,0.0003256684,0.0003498785],"domain_scores_gemma":[0.9992281,0.00008516961,0.00006064122,0.0002967085,0.0001126678,0.00021672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002091239,0.003266524,0.01128142,0.001006506,0.000249285,0.0003578134,0.004856925,0.06020012,0.6441998,0.003259032,0.0002050711,0.2690262],"study_design_scores_gemma":[0.002769632,0.0003934026,0.08903665,0.001312719,0.0002115216,0.00001051449,0.0002604323,0.8565073,0.0474501,0.001575367,0.0001806407,0.0002917263],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717261,0.00302895,0.02289998,0.0005310631,0.0001213158,0.001427246,0.0001350455,0.00005970621,0.00007054431],"genre_scores_gemma":[0.9878582,0.00009730893,0.01087337,0.0003948485,0.00002591341,0.00059597,0.00003960766,0.00001871326,0.0000961128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7963071,"threshold_uncertainty_score":0.4631647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409128664428321,"score_gpt":0.3009081551471629,"score_spread":0.2768168685028797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}