{"id":"W4404829448","doi":"10.1002/advs.202407572","title":"Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science for Life Laboratory; Vetenskapsrådet; Université de Bordeaux; FP7 Ideas: European Research Council; Knut och Alice Wallenbergs Stiftelse; Novo Nordisk Fonden; Svenska Sällskapet för Medicinsk Forskning; Robert Bosch Stiftung; European Commission; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen; H2020 Society; Diamond Light Source; Novo Nordisk; European Federation of Pharmaceutical Industries and Associations; McGill University; Åke Wiberg Stiftelse","keywords":"Steatohepatitis; Dyslipidemia; Fatty liver; Steatosis; Drug discovery; Medicine; Fibrosis; Bioinformatics; Cancer research; Disease; Pathology; Pharmacology; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002406429,0.0003494656,0.0003518627,0.0002230362,0.0001243372,0.0002615734,0.0001848836,0.0004871134,0.001376792],"category_scores_gemma":[0.00009749575,0.0001282994,0.0004563701,0.0001348567,0.000167628,0.0001106854,0.0002413794,0.000672266,0.0003970344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002500773,"about_ca_system_score_gemma":0.0001699682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004046861,"about_ca_topic_score_gemma":0.0005899351,"domain_scores_codex":[0.9998327,0.00002748389,0.000009232325,0.00003845746,0.00005889625,0.00003321117],"domain_scores_gemma":[0.9999199,0.00001417266,0.00002202002,0.00001303196,0.00001198199,0.00001877049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007659662,0.00002722267,0.0001596797,0.00002044632,0.000005946592,0.00004649166,0.000005477453,0.0002325222,0.9985113,0.00005200571,0.00007848884,0.0007839399],"study_design_scores_gemma":[0.00003176918,0.0006782511,0.002895917,0.000005775631,0.00003250852,0.0002899479,0.00003081913,0.004443456,0.988755,0.00008195893,0.002743046,0.0000116063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705271,0.0009556585,0.02411437,0.0003510384,0.00009780436,0.0001172199,0.001957043,0.0004037746,0.001476115],"genre_scores_gemma":[0.982201,0.0006805034,0.01282159,0.0002618478,0.00001141532,0.0002177741,0.001403295,0.00005327417,0.002349369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001376792,"threshold_uncertainty_score":0.00460577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409128664428321,"score_gpt":0.3009081551471629,"score_spread":0.2768168685028797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}