{"id":"W4404838925","doi":"10.1016/j.cels.2024.11.001","title":"Tracking the gene expression programs and clonal relationships that underlie mast, myeloid, and T lineage specification from stem cells","year":2024,"lang":"en","type":"article","venue":"Cell Systems","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Université de Montréal; Institute for Research in Immunology and Cancer; University of British Columbia; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Wellcome Leap; Royal Commission for the Exhibition of 1851; Michael Smith Health Research BC; Allen Institute; European Molecular Biology Organization","keywords":"Stem cell; Biology; Lineage (genetic); Myeloid; Gene; Cell lineage; Gene expression; Gene expression profiling; Mast (botany); Genetics; Mast cell; Cell biology; Cellular differentiation; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491451,0.00009310615,0.0001151444,0.000272463,0.000260522,0.0003726649,0.0001633413,0.00020103,0.0008612014],"category_scores_gemma":[0.0002389198,0.000141855,0.0001246817,0.0003133191,0.0002331183,0.0002053062,0.0001621685,0.0003243616,0.0002518198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003917463,"about_ca_system_score_gemma":0.0002553541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001680459,"about_ca_topic_score_gemma":0.003748999,"domain_scores_codex":[0.9999007,0.000008176043,0.000004609822,0.00004083871,0.00003146303,0.00001414511],"domain_scores_gemma":[0.9998899,0.0000342216,0.00002885636,0.00001327076,0.00002134784,0.00001243172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000241531,0.000005703136,0.002072269,0.00001836555,0.000002919554,0.00001731939,0.00003105309,0.0004494019,0.993393,0.0006509966,0.00007927038,0.003255466],"study_design_scores_gemma":[0.000005923167,0.00006272161,0.03610472,0.000008985066,0.00001422997,0.00009465153,0.00009548464,0.01483979,0.945304,0.0007055646,0.002752541,0.00001129715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951269,0.0004395373,0.04275763,0.00007942459,0.00001612837,0.0000353406,0.002807671,0.0002773552,0.002317899],"genre_scores_gemma":[0.9695439,0.0005313287,0.02597554,0.00005869368,0.000006960837,0.00006876969,0.001470473,0.00006279528,0.002281687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001680459,"threshold_uncertainty_score":0.003341317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05850306888950981,"score_gpt":0.2196282022808357,"score_spread":0.1611251333913259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}