{"id":"W4404841140","doi":"10.7554/elife.83288","title":"Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Western University; McMaster University; McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Biology; H3K4me3; Epigenetics; Sperm; Transcriptome; Chromatin immunoprecipitation; DNA methylation; Genomic imprinting; Histone H3; Offspring; Chromatin; Genetics; Histone methylation; Placenta; Andrology; Gene; Gene expression; Promoter; Pregnancy; Fetus; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001664771,0.0002086532,0.0001539634,0.0002349684,0.0001111429,0.0002448675,0.0001143726,0.000156595,0.001262818],"category_scores_gemma":[0.0001434326,0.0002186378,0.0002367948,0.0001806444,0.0001955348,0.0001167012,0.0001953637,0.0003154108,0.0001935214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001665155,"about_ca_system_score_gemma":0.0001462108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009558885,"about_ca_topic_score_gemma":0.002790907,"domain_scores_codex":[0.9998763,0.00001435302,0.000007903574,0.00004906779,0.00002824678,0.00002418959],"domain_scores_gemma":[0.9998438,0.00002535626,0.00005873317,0.00001874309,0.00002146301,0.00003186574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002604593,0.000009424851,0.007312682,0.00002843769,0.00001810297,0.00003567205,0.00002843237,0.00003090207,0.9903756,0.00006216322,0.00002207779,0.001816144],"study_design_scores_gemma":[0.00001820979,0.0004441433,0.4694266,0.00001507854,0.00009827262,0.0004297287,0.000130391,0.0007367744,0.5270213,0.0001311457,0.001535718,0.00001261355],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946758,0.001065667,0.002627632,0.0000428924,0.00001375461,0.000006842753,0.0008368655,0.00002358338,0.0007069168],"genre_scores_gemma":[0.9937968,0.0009363028,0.00192296,0.00008669784,0.00000694315,0.00001638202,0.0009741251,0.0000355756,0.002224183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262818,"threshold_uncertainty_score":0.004224539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006483420902366892,"score_gpt":0.2476123518119124,"score_spread":0.2411289309095455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}