{"id":"W4404845595","doi":"10.1111/cts.70083","title":"Pharmacogenetic‐guided dosing for fluoropyrimidine (<i>DPYD</i>) and irinotecan (<i>UGT1A1*28</i>) chemotherapies for patients with cancer (<scp>PACIFIC</scp>‐<scp>PGx</scp>): A multicenter clinical trial","year":2024,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Melbourne; International Society of Oncology Pharmacy Practitioners","keywords":"DPYD; Irinotecan; Medicine; Dosing; Pharmacogenetics; Internal medicine; Genotyping; Genotype; Oncology; Pharmacology; Gastroenterology; Cancer; Colorectal cancer; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00194164,0.0004997667,0.0005904298,0.0001784803,0.0002563662,0.000456148,0.000400792,0.0007162863,0.001271354],"category_scores_gemma":[0.001385328,0.0003032977,0.0007633137,0.0002625645,0.0005338248,0.0003608457,0.0003129113,0.001276186,0.0001931465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000663261,"about_ca_system_score_gemma":0.00116467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001317844,"about_ca_topic_score_gemma":0.002444446,"domain_scores_codex":[0.9992272,0.0005094869,0.00004067851,0.0001113733,0.00005412173,0.0000572092],"domain_scores_gemma":[0.9991772,0.0001339662,0.0003256128,0.0000751298,0.00003555073,0.0002525476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7389684,0.044904,0.04895566,0.0003546943,0.001053849,0.0001751886,0.0003458649,0.003946979,0.02461207,0.0003451296,0.001809473,0.1345287],"study_design_scores_gemma":[0.4163818,0.4889592,0.0810326,0.00003219806,0.0008193364,0.0003171688,0.00005491301,0.003581319,0.005661781,0.000270493,0.002857106,0.00003205877],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979281,0.0002127421,0.0002152326,0.0001801063,0.00001888244,0.0006758081,0.0001373201,0.00001588633,0.0006157867],"genre_scores_gemma":[0.997264,0.0001981504,0.00096898,0.0003273702,0.0000370109,0.0005587628,0.000200423,0.00000407253,0.0004411609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00194164,"threshold_uncertainty_score":0.01026845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05301630277024176,"score_gpt":0.3825102109751812,"score_spread":0.3294939082049395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}