{"id":"W4404845595","doi":"10.1111/cts.70083","title":"Pharmacogenetic‐guided dosing for fluoropyrimidine (<i>DPYD</i>) and irinotecan (<i>UGT1A1*28</i>) chemotherapies for patients with cancer (<scp>PACIFIC</scp>‐<scp>PGx</scp>): A multicenter clinical trial","year":2024,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Melbourne; International Society of Oncology Pharmacy Practitioners","keywords":"DPYD; Irinotecan; Medicine; Dosing; Pharmacogenetics; Internal medicine; Genotyping; Genotype; Oncology; Pharmacology; Gastroenterology; Cancer; Colorectal cancer; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001028435,0.000244376,0.000303871,0.00005502082,0.0002799789,0.0001660402,0.0002024485,0.0001717021,0.000003675319],"category_scores_gemma":[0.0002031052,0.0001890862,0.0001957435,0.0001607673,0.0008404598,0.00002943652,0.00004775555,0.000146786,7.348698e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008744981,"about_ca_system_score_gemma":0.0003099731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006253387,"about_ca_topic_score_gemma":0.00001514214,"domain_scores_codex":[0.9977058,0.00004491456,0.0006173661,0.0009284577,0.0002878252,0.0004156383],"domain_scores_gemma":[0.9985458,0.0006578957,0.000115404,0.000151777,0.0002588827,0.0002702556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01458036,0.002922028,0.05411302,0.0006229307,0.001485529,0.000004228973,0.0013959,0.0001320548,0.3736435,0.003422418,0.005048096,0.54263],"study_design_scores_gemma":[0.1036018,0.008876233,0.03111743,0.0002879582,0.000784433,0.00001027291,0.0001785451,0.01991522,0.1129187,0.004423062,0.7173499,0.0005364265],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803157,0.003062484,0.01324588,0.0004452419,0.001057639,0.001403156,0.0003662599,0.00002558355,0.00007806114],"genre_scores_gemma":[0.9893524,0.001944075,0.006236842,0.0008534653,0.00103381,0.000192758,0.00007266019,0.00003896262,0.0002750007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7123019,"threshold_uncertainty_score":0.7710712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05301630277024176,"score_gpt":0.3825102109751812,"score_spread":0.3294939082049395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}