{"id":"W4404851334","doi":"10.1016/j.gene.2024.149129","title":"MicroRNA-34a-5p regulates agouti-related peptide via krüppel-like factor 4 and is disrupted by bisphenol A in hypothalamic neurons","year":2024,"lang":"en","type":"article","venue":"Gene","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Biology; Krüppel; microRNA; Bisphenol A; Peptide; Cell biology; Internal medicine; Endocrinology; Transcription factor; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756568,0.0005119765,0.0003801354,0.0003960419,0.0003475285,0.0003423063,0.0003041394,0.0003236919,0.001054758],"category_scores_gemma":[0.0002454041,0.0003768296,0.0007244739,0.0001621475,0.0003646495,0.0001767281,0.0004064402,0.0007166502,0.0005647371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005936776,"about_ca_system_score_gemma":0.0004671574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001654881,"about_ca_topic_score_gemma":0.001871114,"domain_scores_codex":[0.9996816,0.00003585954,0.00004186891,0.00007979495,0.0001049686,0.00005592814],"domain_scores_gemma":[0.9998587,0.00001881494,0.00006503722,0.00001211782,0.00001564574,0.00002960259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001503383,0.00001759847,0.0003794236,0.00003279869,0.00001316323,0.0001453778,0.0000185557,0.0001269536,0.9980032,0.0001292125,0.00006594346,0.0009174371],"study_design_scores_gemma":[0.00003205332,0.0001340953,0.01682622,0.0000125165,0.0000530241,0.0005452876,0.00006470356,0.004017602,0.9739985,0.0002369453,0.004058789,0.00002026485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822036,0.001662268,0.01082229,0.0002870522,0.0001419887,0.00005760369,0.001766853,0.0004246019,0.002633635],"genre_scores_gemma":[0.9874498,0.0007808751,0.006335753,0.0002424808,0.00001170254,0.000105175,0.001355416,0.0001323658,0.003586456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001654881,"threshold_uncertainty_score":0.004307449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005642452941233005,"score_gpt":0.2234753997772777,"score_spread":0.2178329468360447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}