{"id":"W4404857070","doi":"10.1016/j.ymthe.2024.11.026","title":"Second gene therapy for hemophilia B approved: More answers or questions?","year":2024,"lang":"en","type":"editorial","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Genetic enhancement; Medicine; Virology; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01038021,0.003014907,0.004048333,0.002244962,0.003029772,0.007115002,0.00411402,0.02837786,0.01177097],"category_scores_gemma":[0.01978519,0.001153389,0.002549119,0.001070629,0.002874211,0.004460883,0.001360401,0.02989403,0.007414077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004648096,"about_ca_system_score_gemma":0.004236272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002680422,"about_ca_topic_score_gemma":0.00640353,"domain_scores_codex":[0.9941015,0.001325792,0.0006533657,0.0005733094,0.00284766,0.0004984058],"domain_scores_gemma":[0.9830943,0.007736707,0.0008917914,0.0004327079,0.005117965,0.002726434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005132184,0.00001760256,0.0000159958,0.0001695472,0.00001871238,0.0001038886,0.000008173921,0.00001939024,0.00007511231,0.0004754108,0.9945804,0.00446434],"study_design_scores_gemma":[0.0001161554,0.00005466018,0.0002265234,0.0003591592,0.00007392003,0.0002583271,0.00003463383,0.0001835384,0.0001575627,0.001569776,0.9969395,0.00002634127],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0000476125,0.0115383,0.0001369986,0.06277465,0.9227823,0.00001802843,0.00004122193,0.00004534776,0.002615433],"genre_scores_gemma":[0.0006277578,0.007686988,0.0001878122,0.06423563,0.9117798,0.00002793582,0.00003745713,0.00003819988,0.01537844],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.02837786,"threshold_uncertainty_score":0.05489647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578852260143728,"score_gpt":0.3253221701617404,"score_spread":0.3095336475603031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}