{"id":"W4404857469","doi":"10.1093/noajnl/vdae173.035","title":"10311- ACT-19 A GLOBAL, RANDOMIZED, DOUBLE-BLINDED, PHASE 3 STUDY OF VORASIDENIB VERSUS PLACEBO IN PATIENTS WITH ADULT-TYPE DIFFUSE GLIOMA WITH AN IDH1/2 MUTATION (INDIGO): UPDATED EFFICACY RESULTS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"University of California, Los Angeles; Universitätsklinikum Heidelberg; Servier; Memorial Sloan-Kettering Cancer Center; University of Utah; Tel Aviv University; Sorbonne Université; Deutsches Krebsforschungszentrum; Huntsman Cancer Institute","keywords":"Placebo; Glioma; IDH1; Double blinded; Medicine; Internal medicine; Mutation; Oncology; Biology; Genetics; Cancer research; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002458078,0.0004209404,0.001100509,0.0004182268,0.00009238135,0.00004464537,0.0001609069,0.0001508163,0.00001833926],"category_scores_gemma":[0.000428296,0.0002750509,0.0000789806,0.001389302,0.0002497245,0.0004632968,0.00004215603,0.0002893526,0.00001594112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002795178,"about_ca_system_score_gemma":0.000347777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002738178,"about_ca_topic_score_gemma":0.002125373,"domain_scores_codex":[0.9969268,0.0004467908,0.0007690053,0.0008714047,0.0005809326,0.0004050502],"domain_scores_gemma":[0.9973599,0.001181747,0.0003759878,0.000482033,0.0003679729,0.0002323909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9321772,0.02179025,0.03201666,0.00006156801,0.0005966463,0.004625162,0.001687624,0.0006724994,0.0001782467,0.00004389995,0.00007445984,0.006075741],"study_design_scores_gemma":[0.932252,0.04775067,0.01538251,0.0001619933,0.001179512,0.000101702,0.001146017,0.0002411869,0.001197749,0.00001808783,0.0003167751,0.0002517205],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927501,0.0003772658,0.000007126413,0.0003841443,0.0005706986,0.005506471,0.00005396558,0.0001486934,0.0002015021],"genre_scores_gemma":[0.9988013,0.00007223814,0.0002650114,0.00008512293,0.00005740723,0.0003553113,0.0003175603,0.00004325049,0.000002828308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02596042,"threshold_uncertainty_score":0.9999701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022971997088449,"score_gpt":0.3555558387107033,"score_spread":0.3325838416222544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}