{"id":"W4404857469","doi":"10.1093/noajnl/vdae173.035","title":"10311- ACT-19 A GLOBAL, RANDOMIZED, DOUBLE-BLINDED, PHASE 3 STUDY OF VORASIDENIB VERSUS PLACEBO IN PATIENTS WITH ADULT-TYPE DIFFUSE GLIOMA WITH AN IDH1/2 MUTATION (INDIGO): UPDATED EFFICACY RESULTS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"University of California, Los Angeles; Universitätsklinikum Heidelberg; Servier; Memorial Sloan-Kettering Cancer Center; University of Utah; Tel Aviv University; Sorbonne Université; Deutsches Krebsforschungszentrum; Huntsman Cancer Institute","keywords":"Placebo; Glioma; IDH1; Double blinded; Medicine; Internal medicine; Mutation; Oncology; Biology; Genetics; Cancer research; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002746201,0.00159827,0.002947122,0.0005893026,0.000418034,0.001416953,0.001069648,0.001335447,0.00744907],"category_scores_gemma":[0.001364394,0.00071993,0.001825539,0.0006742541,0.001022505,0.0008238307,0.000308865,0.002950302,0.001395104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008436659,"about_ca_system_score_gemma":0.00204733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009184193,"about_ca_topic_score_gemma":0.003984843,"domain_scores_codex":[0.9989015,0.0006394743,0.00006605974,0.00014853,0.0001075787,0.0001369089],"domain_scores_gemma":[0.9993831,0.0001190701,0.0001706686,0.00004586404,0.00006807924,0.0002131964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9175788,0.009721313,0.001467322,0.001562906,0.002429267,0.00008070264,0.00008730698,0.0006690628,0.009629554,0.0003188362,0.00611433,0.05034067],"study_design_scores_gemma":[0.9464149,0.04712459,0.002440172,0.00004846627,0.0006882073,0.00005138815,0.00001745327,0.0002726346,0.0005743526,0.0001715886,0.002173339,0.00002286291],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9266418,0.02575941,0.002977249,0.002411159,0.001372108,0.01723041,0.01125154,0.0008705083,0.0114858],"genre_scores_gemma":[0.9552597,0.007497106,0.00439287,0.003979533,0.0005651796,0.01536061,0.005415391,0.0001014534,0.007428222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00744907,"threshold_uncertainty_score":0.02491957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022971997088449,"score_gpt":0.3555558387107033,"score_spread":0.3325838416222544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}